Prenatal arsenic exposure alters the placental expression of multiple epigenetic regulators in a sex-dependent manner.

Environmental Health : a Global Access Science Source
Emily F WinterbottomDavid J Robbins

Abstract

Prenatal exposure to arsenic has been linked to a range of adverse health conditions in later life. Such fetal origins of disease are frequently the result of environmental effects on the epigenome, leading to long-term alterations in gene expression. Several studies have demonstrated effects of prenatal arsenic exposure on DNA methylation; however the impact of arsenic on the generation and decoding of post-translational histone modifications (PTHMs) is less well characterized, and has not been studied in the context of prenatal human exposures. In the current study, we examined the effect of exposure to low-to-moderate levels of arsenic in a US birth cohort, on the expression of 138 genes encoding key epigenetic regulators in the fetal portion of the placenta. Our candidate genes included readers, writers and erasers of PTHMs, and chromatin remodelers. Arsenic exposure was associated with the expression of 27 of the 138 epigenetic genes analyzed. When the cohort was stratified by fetal sex, arsenic exposure was associated with the expression of 40 genes in male fetal placenta, and only 3 non-overlapping genes in female fetal placenta. In particular, we identified an inverse relationship between arsenic exposure and expression...Continue Reading

References

Feb 18, 2004·Molecular and Cellular Biology·Yannick DoyonJacques Côté
Jun 16, 2004·Current Opinion in Genetics & Development·Yannick Doyon, Jacques Côté
Mar 16, 2006·Molecular and Cellular Biology·Christopher A DavisEric N Olson
Feb 20, 2007·The Journal of Pediatrics·Ronald I Clyman, Nancy Chorne
Mar 5, 2009·American Journal of Epidemiology·Matthew J StricklandPaige E Tolbert
Nov 24, 2011·Nature Reviews. Molecular Cell Biology·Bernd SchuettengruberGiacomo Cavalli
Dec 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Diane Gilbert-DiamondMargaret R Karagas
Oct 16, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yana ChervonaMax Costa
Jun 13, 2013·Environmental Health Perspectives·Devin C KoestlerCarmen J Marsit
Jul 19, 2013·Toxicology and Applied Pharmacology·Shohreh F FarzanYu Chen
Jul 23, 2013·Environmental Health : a Global Access Science Source·Dennis Liang FeiDavid J Robbins
Feb 6, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Chiara PastoriNagi G Ayad
May 27, 2014·Current Environmental Health Reports·Kathryn A Bailey, Rebecca C Fry
Jun 12, 2014·International Journal of Hygiene and Environmental Health·Tamás RudnaiPéter Rudnai
Jun 27, 2014·Journal of Developmental Origins of Health and Disease·K BrobergM Vahter
Sep 18, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Kari C NadeauMargaret R Karagas
May 15, 2015·Environmental Health : a Global Access Science Source·Matthew A DavisMargaret R Karagas
Jul 15, 2015·Database : the Journal of Biological Databases and Curation·Yulia A MedvedevaFinn Drabløs
Aug 20, 2015·EBioMedicine·Emily F WinterbottomDavid J Robbins
Sep 12, 2015·Environmental Health Perspectives·Shohreh F FarzanMargaret R Karagas
Sep 14, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Megan M NiedzwieckiMary V Gamble
Apr 15, 2017·Environmental Research·Shohreh F FarzanMargaret R Karagas
Jun 16, 2017·Environmental Health : a Global Access Science Source·Emily F WinterbottomDavid J Robbins
Oct 19, 2017·International Journal of Epidemiology·Katherine A MoonAna Navas-Acien
Jul 1, 2015·Environmental Research Letters : ERL [Web Site]·Lan JinYawei Zhang

❮ Previous
Next ❯

Citations

Jan 18, 2020·Environmental Health Perspectives·Felicia Fei-Lei Chung, Zdenko Herceg
Jun 10, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kevin S HsuRichard I Enelow
Jun 10, 2019·Environmental and Molecular Mutagenesis·Bambarendage P U PereraDana C Dolinoy
Aug 31, 2020·Epigenetics Insights·Laurie K SvobodaDana C Dolinoy
Apr 4, 2021·International Journal of Molecular Sciences·Ho-Wei HsuJong-Hau Hsu
Apr 16, 2021·Advanced Science·Yingyun GongZheng Sun
Oct 19, 2021·Frontiers in Genetics·Victor D Martinez, Wan L Lam

❮ Previous
Next ❯

Methods Mentioned

BETA
ubiquitination
urine sample collection
biopsy
biopsies
acetylation

Software Mentioned

R
NanoString
nSolver

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.