Prenatal bisphenol a exposure and dysregulation of infant hypothalamic-pituitary-adrenal axis function: findings from the APrON cohort study

Environmental Health : a Global Access Science Source
Gerald F GiesbrechtAPrON Study Team

Abstract

Animal models show that prenatal bisphenol A (BPA) exposure leads to sexually dimorphic disruption of the neuroendocrine system in offspring, including the hypothalamic-pituitary-adrenal (HPA) neuroendocrine system, but human data are lacking. In humans, prenatal BPA exposure is associated with sex-specific behavioural problems in children, and HPA axis dysregulation may be a biological mechanism. The objective of the current study was to examine sex differences in associations between prenatal maternal urinary BPA concentration and HPA axis function in 3 month old infants. Mother-infant pairs (n = 132) were part of the Alberta Pregnancy Outcomes and Nutrition study, a longitudinal birth cohort recruited (2010-2012) during pregnancy. Maternal spot urine samples collected during the 2nd trimester were analyzed for total BPA and creatinine. Infant saliva samples collected prior to and after a blood draw were analyzed for cortisol. Linear growth curve models were used to characterize changes in infant cortisol as a function of prenatal BPA exposure. Higher maternal BPA was associated with increases in baseline cortisol among females (β = 0.13 log μg/dL; 95% CI: 0.01, 0.26), but decreases among males (β = -0.22 log μg/dL; 95% CI: -...Continue Reading

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Citations

Jun 9, 2018·Journal of Clinical Medicine·Burcin SanlidagNerin N Bahçeciler
Dec 2, 2020·International Journal of Molecular Sciences·Gianna RossiMauro Maccarrone
Jul 13, 2019·Environmental Research·Ya MaHuizhen Zhang
Jan 21, 2021·International Journal of Environmental Research and Public Health·Francesca FarrugiaNikolai Paul Pace
Jan 4, 2021·Endocrine Reviews·Vasantha PadmanabhanMuraly Puttabyatappa
Apr 25, 2021·European Journal of Pediatrics·Sarah ZulkifliNoor Shafina Mohd Nor

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Methods Mentioned

BETA
blood draw
urine collection
circumcision

Software Mentioned

SPSS

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