Abstract
The altered expression pattern of miRNAs might potentially reflect anomalies related to foetal chromosomal aberrations. The aim of the study was to determine the expression level of miRNAs in plasma of pregnant women with foetal Down syndrome (DS). Out of 198 amniocentesis performed at 15-18 weeks of gestation, within a group of 12 patients with foetal DS and 12 patients with uncomplicated pregnancies, who delivered healthy newborns at term, we examined the expression level of 800 miRNAs using the NanoString technology. Our study revealed that there are 6 miRNAs were upregulated (hsa-miR-15a, hsa-let-7d, hsa-miR-142, hsa-miR-23a, hsa-miR-199, hsa-miR-191) and 7 were downregulated (hsa-miR-1290, hsa-miR-1915, hsa-miR30e, hsa-miR-1260, hsa-miR-483, hsa-miR-548, hsa-miR-590) in plasma samples of women with foetal DS syndrome. The genes regulated by identified miRNAs are involved in central nervous system development, congenital abnormalities and heart defects. The results of the present study yielded information on DS-specific miRNA expression signature, which can further help to design a panel of miRNAs as a non-invasive test for DS diagnosis. We believe that identified miRNAs may attend in the pathogenesis of DS and would potent...Continue Reading
References
Feb 17, 2001·Prenatal Diagnosis·P A BennJ F Egan
Mar 1, 2002·Human Reproduction·F VesceA Piffanelli
Jun 24, 2004·Nature Reviews. Genetics·Lin He, Gregory J Hannon
Nov 13, 2004·Nature·Matthew N PoyMarkus Stoffel
Feb 3, 2005·Nature·Lee P LimJason M Johnson
Apr 5, 2005·Nature Genetics·Azra KrekNikolaus Rajewsky
Oct 15, 2005·Science·Jesse F AbelsonMatthew W State
Dec 31, 2005·Nucleic Acids Research·Sam Griffiths-JonesAnton J Enright
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stefano VoliniaCarlo M Croce
Sep 6, 2007·Genome Biology·Da Wei HuangRichard A Lempicki
Oct 3, 2007·Mental Retardation and Developmental Disabilities Research Reviews·Stephanie L ShermanSallie B Freeman
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Jun 18, 2009·American Journal of Medical Genetics. Part a·Sujoy GhoshSubrata Kumar Dey
Sep 15, 2010·BMC Medical Genomics·Valerio CostaClaudio Napoli
Jan 13, 2011·BMJ : British Medical Journal·Rossa W K ChiuY M Dennis Lo
Feb 12, 2011·American Journal of Obstetrics and Gynecology·Mathias EhrichDirk van den Boom
Oct 19, 2011·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Glenn E PalomakiJacob A Canick
Jan 10, 2012·Prenatal Diagnosis·Andrew B SparksArnold Oliphant
Jan 15, 2013·American Journal of Obstetrics and Gynecology·Ray O Bahado-SinghKypros Nicolaides
Sep 28, 2013·International Journal of Molecular Medicine·Yong XuYong Dai
Dec 18, 2013·Bioinformatics·Andreas KrämerStuart Tugendreich
Dec 6, 2014·Mediators of Inflammation·Piotr LaudanskiRadoslaw Charkiewicz
Mar 10, 2015·Journal of Assisted Reproduction and Genetics·Ji Hyae LimSo Yeon Park
May 23, 2015·PloS One·Karol CharkiewiczPiotr Laudanski
Apr 26, 2016·BioMed Research International·Biray ErturkOzgur Cogulu
Apr 28, 2016·Clinical Chemistry·George KoumbarisPhilippos C Patsalis
May 21, 2016·Journal of Translational Medicine·Lyudmila F Gulyaeva, Nicolay E Kushlinskiy
Jun 9, 2016·Journal of Biomedical Science·Wei-Li ShiShi-Xiu Liao
Aug 20, 2016·Inflammatory Bowel Diseases·Angelos OikonomopoulosDimitrios Iliopoulos
Citations
May 31, 2020·Molecular Biology Reports·Iveta ZedníkováAleš Hořínek
Aug 23, 2020·Diagnostics·Michał KuncElżbieta Senkus-Konefka
Jan 24, 2020·Journal of Translational Medicine·Haiou YangZhenhua Tang
Nov 27, 2020·Frontiers in Neurology·Dmytro GerasymchukAndrii Domanskyi
Mar 29, 2021·Journal of Molecular Neuroscience : MN·Iman Imtiyaz Ahmed Juvale, Ahmad Tarmizi Che Has
Jul 30, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Mohammad Reza KarimzadehMaria Nezamnia
Jul 25, 2021·International Journal of Molecular Sciences·Chiara De Santis, Martin Götte
Feb 3, 2020·Experimental and Molecular Pathology·Sensen LiYaojun Li