PMID: 8971989Nov 1, 1996Paper

Prenatal cocaine: effect on hypoxic ventilatory responsiveness in neonatal rats

Respiration Physiology
J W LiptonD E Weese-Mayer

Abstract

The effects of prenatal (embryonic days 7-21) cocaine (30 mg/kg b.i.d., s.c.) exposure on postnatal respiratory and behavioral responsiveness to acute hypoxia were investigated in 5-day-old (P5) rat pups. Control and cocaine-exposed pups were subjected to 20 min of 0.21 FIO2 followed by 20 min of 0.08 FIO2. Although all pups demonstrated the characteristic biphasic response to hypoxia, cocaine-exposed pups exhibited a blunted, initial response in minute ventilation (p < 0.05) and inspiratory drive (p < 0.05) as compared with control pups who showed increases in these measures (p < 0.01 and p < 0.05, respectively). The consequence of this apparent blunted ventilatory response was reflected in blood gas data gathered after 20 min of 0.08 FIO2:PCO2 (p < 0.05) and base-excess (p < 0.05) were increased and HCO3- (p < 0.05) and SO2 (p < 0.01) were decreased relative to control pups. Cocaine-exposed pups also exhibited behavioral evidence of decreased struggling (p < 0.001) in response to the hypoxic challenge. These data in the rat confirm our previous findings of altered ventilatory responsiveness to inspired hypoxia in the rabbit and extend our observations of a decreased ability to successfully compensate and behaviorally arouse f...Continue Reading

References

Nov 1, 1992·The Journal of Pediatrics·S L WardX Bean
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Dec 1, 1991·Early Human Development·E M McCann, K Lewis
Jan 1, 1991·The Journal of Pediatrics·S E LipshultzE J Orav
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Apr 1, 1993·Proceedings of the Society for Experimental Biology and Medicine·L P Sandstrom, S N Pennington

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Citations

Jan 27, 2004·Brain Research. Developmental Brain Research·Jack W LiptonSusan O McGuire
Apr 12, 2002·Neurotoxicology and Teratology·Jack W LiptonPaul M Carvey
Jan 21, 2000·Neurotoxicology and Teratology·I R Moss, A Laferrière
Jul 21, 1998·Annals of the New York Academy of Sciences·J W LiptonP M Carvey
Jul 21, 1998·Annals of the New York Academy of Sciences·A N DaviesP D Brown-Woodman
Jun 28, 2016·Birth Defects Research. Part C, Embryo Today : Reviews·Melissa M MartinGregg D Stanwood
Oct 27, 1999·Pediatric Pulmonology·A E Waddell, J T Fisher
Feb 25, 1998·Pediatric Pulmonology·I R Moss, A Laferrière
Apr 13, 2018·The Journal of Physiology·Andrea PorzionatoRaffaele De Caro
Nov 8, 2002·Pediatric Pulmonology·Fanny AutretJorge Gallego
Jan 12, 2008·Journal of Applied Physiology·Ryan W Bavis, Gordon S Mitchell
Jun 1, 1998·Annals of the New York Academy of Sciences·A N DaviesP D C Brown-Woodman
May 1, 1998·Annals of the New York Academy of Sciences·Jack W LiptonPaul M Carvey

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