Prenatal cocaine exposure alters alpha2 receptor expression in adolescent rats.

BMC Neuroscience
Rosemarie M BoozeCharles F Mactutus

Abstract

Prenatal cocaine exposure produces attentional deficits which to persist through early childhood. Given the role of norepinephrine (NE) in attentional processes, we examined the forebrain NE systems from prenatal cocaine exposed rats. Cocaine was administered during pregnancy via the clinically relevant intravenous route of administration. Specifically, we measured alpha2-adrenergic receptor (alpha2-AR) density in adolescent (35-days-old) rats, using [3H]RX821002 (5 nM). Sex-specific alterations of alpha2-AR were found in the hippocampus and amygdala of the cocaine-exposed animals, as well as an upregulation of alpha2-AR in parietal cortex. These data suggest that prenatal cocaine exposure results in a persistent alteration in forebrain NE systems as indicated by alterations in receptor density. These neurochemical changes may underlie behavioral abnormalities observed in offspring attentional processes following prenatal exposure to cocaine.

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Citations

May 15, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kalindi BakshiHoau-Yan Wang
Mar 15, 2014·PloS One·Kalindi BakshiHoau-Yan Wang
Apr 24, 2015·Acta Neuropsychiatrica·Thea Pinholt LillethorupAnne Marlene Landau
Jan 22, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Thea P LillethorupAnne M Landau
Oct 16, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Mark J FerrisRosemarie M Booze
Nov 29, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Dhyanesh Arvind PatelCharles F Mactutus
Aug 7, 2016·PloS One·Andres StuckyHoau-Yan Wang
Jan 15, 2009·Biological Research for Nursing·Sun-Mi Chae, Chandice Y Covington
Jul 9, 2020·The Journal of Pharmacology and Experimental Therapeutics·Paul W Czoty, Michael A Nader
Dec 6, 2019·Pharmacology, Biochemistry, and Behavior·Rochelle N WickramasekaraDeniz Yilmazer-Hanke

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Methods Mentioned

BETA
scintillation
X-ray

Software Mentioned

GraphPAD
MCID
BMDP
PRISM

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