Prenatal cocaine exposure decreases parvalbumin-immunoreactive neurons and GABA-to-projection neuron ratio in the medial prefrontal cortex.

Developmental Neuroscience
Deirdre M McCarthy, Pradeep G Bhide

Abstract

Cocaine abuse during pregnancy produces harmful effects not only on the mother but also on the unborn child. The neurotransmitters dopamine and serotonin are known as the principal targets of the action of cocaine in the fetal and postnatal brain. However, recent evidence suggests that cocaine can impair cerebral cortical GABA neuron development and function. We sought to analyze the effects of prenatal cocaine exposure on the number and distribution of GABA and projection neurons (inhibitory interneurons and excitatory output neurons, respectively) in the mouse cerebral cortex. We found that the prenatal cocaine exposure decreased GABA neuron numbers and GABA-to-projection neuron ratio in the medial prefrontal cortex of 60-day-old mice. The neighboring prefrontal cortex did not show significant changes in either of these measures. However, there was a significant increase in projection neuron numbers in the prefrontal cortex but not in the medial prefrontal cortex. Thus, the effects of cocaine on GABA and projection neurons appear to be cortical region specific. The population of parvalbumin-immunoreactive GABA neurons was decreased in the medial prefrontal cortex following the prenatal cocaine exposure. The cocaine exposure a...Continue Reading

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Citations

Sep 29, 2012·Developmental Neuroscience·Deirdre M McCarthyPradeep G Bhide
Aug 29, 2013·Neurotoxicology and Teratology·Gale A RichardsonNancy L Day
Aug 9, 2013·Science Translational Medicine·Zeeba D KabirBarry E Kosofsky
Dec 3, 2015·Drug and Alcohol Dependence·Sarah W YipMarc N Potenza
Jun 28, 2016·Birth Defects Research. Part C, Embryo Today : Reviews·Melissa M MartinGregg D Stanwood
Sep 11, 2012·Journal of Neurodevelopmental Disorders·Florence RoussotteElizabeth Sowell
Jun 7, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sarah W YipMarc N Potenza
Jun 19, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emily J RossGregg D Stanwood
May 10, 2017·Archives of Toxicology·Michaela Fujáková-LipskiRomana Šlamberová
Sep 10, 2017·Drug and Alcohol Dependence·Yasmin ZakiniaeizMarc N Potenza
Nov 14, 2014·ACS Chemical Neuroscience·Devon L GrahamGregg D Stanwood

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