Prenatal Cotinine Levels and ADHD Among Offspring

Pediatrics
Andre SouranderAlan S Brown

Abstract

An association between maternal smoking during pregnancy and offspring attention-deficit/hyperactivity disorder (ADHD) has been shown across several studies based on self-reports. No previous studies have investigated the association of nicotine exposure measured by cotinine levels during pregnancy and offspring ADHD. In this population-based study, 1079 patients born between 1998 and 1999 and diagnosed with ADHD according to the International Classification of Diseases and 1079 matched controls were identified from Finnish nationwide registers. Maternal cotinine levels were measured by using quantitative immunoassays from maternal serum specimens collected during the first and second trimesters of pregnancy and archived in the national biobank. There was a significant association between increasing log-transformed maternal cotinine levels and offspring ADHD. The odds ratio was 1.09 (95% confidence interval [CI] 1.06-1.12) when adjusting for maternal socioeconomic status, maternal age, maternal psychopathology, paternal age, paternal psychopathology, and child's birth weight for gestational age. In the categorical analyses with cotinine levels in 3 groups, heavy nicotine exposure (cotinine level >50 ng/mL) was associated with o...Continue Reading

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Citations

Jan 12, 2020·Birth Defects Research·Santiago CerrizuelaManuel J Aybar
Sep 5, 2020·European Child & Adolescent Psychiatry·Andre SouranderAlan S Brown
Jun 26, 2020·Frontiers in Behavioral Neuroscience·Francesco TraccisMiriam Melis
Apr 4, 2020·European Child & Adolescent Psychiatry·Joana Roigé-CastellvíJosefa Canals
Oct 25, 2020·Environmental Science and Pollution Research International·Anyan HuangYanhong Huang
Dec 22, 2019·Journal of the American Academy of Child and Adolescent Psychiatry·Minna SucksdorffAndre Sourander
Sep 11, 2021·Autism Research : Official Journal of the International Society for Autism Research·Keely Cheslack-PostavaAlan S Brown
Jan 3, 2021·Pediatrics·Jyothi MarbinUNKNOWN SECTION ON TOBACCO CONTROL

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