PMID: 18182350Jan 10, 2008Paper

Prenatal diagnosis and perinatal management of maternal-fetal congenital parvovirus B19 infection

Taiwanese Journal of Obstetrics & Gynecology
Shih-Tien HsuMin-Min Chou

Abstract

In nonimmune pregnant woman, the primary infection with parvovirus B19 may lead to transplacental transmission to the fetus with variable outcomes, including congenital anemia, hydrops fetalis, fetal death or spontaneous resolution. The first case was of a 28-year-old woman, gravida 2, para 1, whose fetus was found to have left-sided pleural effusion on a sonogram at 29 weeks of gestation. A sample of aspirated pleural fluid was positive for parvovirus B19 by polymerase chain reaction. Cordocentesis showed fetal hemoglobin level of 5.0 g/dL. Intraperitoneal transfusion (IPT) was performed, because access to the fetal circulation was difficult. Thirty milliliters of group O, Rh-positive packed red cells were transfused into the peritoneal cavity. A non-hydropic baby weighing 2,680 g was delivered at 33 weeks of gestation. The neonates complete blood count examination showed a hemoglobin level of 16.3 g/dL. The newborn baby was discharged in stable condition. The second case was of a 31-year-old woman, gravida 2, para 1, whose fetus was found to have ascites, hypertrophic cardiomyopathy, and placentomegaly on a sonogram at 23 weeks of gestation. An amniotic fluid sample was positive for parvovirus B19 DNA by polymerase chain reac...Continue Reading

References

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Citations

Feb 2, 2013·Journal of Obstetrics and Gynaecology of India·Deepika DekaSuneeta Mittal
May 19, 2011·FEMS Immunology and Medical Microbiology·Svetoslav N SlavovDimas Tadeu Covas
May 9, 2014·Clinical Pediatrics·Anthony C HudsonRussell W Steele
Feb 18, 2011·Fetal Diagnosis and Therapy·Teresa CarracaNuno Montenegro

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