Prenatal diagnosis of closed spina bifida: multicenter case series and review of the literature

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Hérbene José Figuinha MilaniEdward Araujo Júnior

Abstract

Closed spina bifida (CSB) is an abnormality of the posterior arch formation in which the defect is covered by the skin, without protrusion of nervous tissue. The prenatal diagnosis of CSB is very difficult, rarely diagnosed antenatally. We present a multicenter case series of six prenatal diagnosis of CSB using two-dimensional (2D) ultrasonography complemented with three-dimensional (3D) ultrasonography and magnetic resonance imaging (MRI). All cases of prenatal diagnosis of CSB were confirmed in the postnatal period/termination of pregnancy by both clinical and/or imaging diagnosis (ultrasonography and MRI). 2D ultrasonography allowed the prenatal diagnosis of six cases. We observed two cases of subcutaneous lipomas, two cases of meningoceles, one case of fibrolipomas, and one case of false-positive CSB (meningomyelocele). 3D ultrasonography using rendering mode was important in one case of meningocele (case# 3). Three cases were delivered at term and one of them was submitted to corrective surgery. All these three newborns were discharged from the hospital well and without neurologic signs. Termination of pregnancy was performed in three cases. During prenatal evaluation, detailed ultrasonographic assessment of the entire spi...Continue Reading

References

Jul 12, 1986·Lancet·K H NicolaidesR Guidetti
Feb 2, 1999·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·T S SattarS Rimmer
Oct 25, 2006·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Yaron ZalelReuwen Achiron
Nov 7, 2006·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·T GhiN Rizzo
Jan 4, 2007·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·UNKNOWN International Society of Ultrasound in Obstetrics & Gynecology Education Committee
Nov 18, 2009·Revista da Associação Médica Brasileira·Carlos Noronha NetoAdriana Mota Bione Noronha
Feb 11, 2011·The New England Journal of Medicine·N Scott AdzickUNKNOWN MOMS Investigators
Feb 22, 2012·Gastroenterology Clinics of North America·Mohamed O Othman, Michael B Wallace
Oct 25, 2014·Fetal Diagnosis and Therapy·Beverly G ColemanSteven C Horii
Jun 9, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Waldo SepulvedaFelipe Otayza

❮ Previous
Next ❯

Citations

Jul 22, 2020·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Yimei LiaoShengli Li
Feb 23, 2021·Intractable & Rare Diseases Research·Mohamad MoussaAthanasios Dellis
Jun 3, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Francisco Sepulveda, Waldo Sepulveda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.