Prenatal diagnosis of congenital heart disease; prospects and problems

European Journal of Obstetrics, Gynecology, and Reproductive Biology
E BuskensJ W Wladimiroff

Abstract

Routine fetal echocardiography has been submitted as an antenatal screening test for congenital heart disease despite a wide range of efficacy reported. Hence, evaluation of the variable results of prenatal ultrasound screening programs was pursued. As the studies appeared to have a heterogeneous design, the originally reported figures have been corrected for one plausible prevalence of cardiovascular anomalies. Clinical setting (general hospitals vs. teaching hospitals), case ascertainment (retrospective vs. prospective; follow-up on (suspected) cases only vs. routine follow-up) and length of follow-up (< 1 year vs. a longer period) all have similar effects on the reported yield of cases and sensitivity of the proposed screening test. Notably, a relatively low yield of cases causes a seemingly high sensitivity, whereas a higher yield of cases causes a seemingly low sensitivity. Additional factors of study design, e.g. case definition, diagnostic procedures and appliances used, were usually not described in detail, yet may also have affected the results. Evaluating diagnostic tests apparently demands a rigorous study design to overcome biased results. Furthermore, no sufficient evidence could be found meriting current routine p...Continue Reading

References

Jul 1, 1992·Archives of Disease in Childhood·S CullenI D Sullivan
May 11, 1992·American Journal of Obstetrics and Gynecology·B BromleyB R Benacerraf
Mar 1, 1992·British Journal of Obstetrics and Gynaecology·G K Sharland, L D Allan
Dec 1, 1991·The Journal of Thoracic and Cardiovascular Surgery·A C ChangW I Norwood
Jul 1, 1990·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M A RusticoG P Mandruzzato
Jan 1, 1990·British Journal of Obstetrics and Gynaecology·G K DavisM G Chapman
Jun 1, 1989·Obstetrics and Gynecology·H Rosendahl, S Kivenen
Jul 1, 1989·Archives of Disease in Childhood·L D Allan
May 1, 1986·American Journal of Obstetrics and Gynecology·J A CopelC S Kleinman
Jun 28, 1986·British Medical Journal·L D AllanM J Tynan
Feb 1, 1988·American Journal of Obstetrics and Gynecology·J A CopelC S Kleinman
Jan 1, 1987·Fetal Therapy·P A Stewart, J W Wladimiroff
Jan 1, 1987·Fetal Therapy·P A StewartE S Sachs
May 1, 1985·Journal of Clinical Ultrasound : JCU·C S KleinmanJ C Hobbins
Nov 1, 1984·British Heart Journal·L D AllanM J Tynan
Aug 1, 1984·Australasian Radiology·G B Davison
Oct 1, 1980·British Heart Journal·L D AllanR H Anderson
Jan 1, 1994·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·E TegnanderD T Linker

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Citations

Mar 24, 1998·Prenatal Diagnosis·U Gembruch

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