Prenatal diagnosis of hypoplastic left heart syndrome in current era

The American Journal of Cardiology
Alaina K KippsAnita J Moon-Grady

Abstract

We sought to evaluate the relation of a prenatal diagnosis (preDx) with morbidity and mortality during the initial hospitalization in a contemporary cohort of patients with hypoplastic left heart syndrome (HLHS). A retrospective study of patients with HLHS presenting from 1999 to 2010 was performed. Patients with genetic disorders or a gestational age <34 weeks or who had intentionally received comfort care only were excluded. Of the 81 patients meeting the study criteria, 49 had a preDx and 32 were diagnosed postnatally (postDx). Birth weight (median 3.0 vs 3.4 kg; p = 0.007) and gestational age (median 38 vs 39 weeks; p <0.001) were lower in the preDx than in the postDx patients. Preoperatively, the postDx patients were intubated more frequently (97% vs 71%, p = 0.004) and ventilated longer (median 96 vs 24 hours, p = 0.005) than the preDx patients. They also had more preoperative acidosis, multiorgan failure, tricuspid valve regurgitation, and right ventricular dysfunction. Of the 73 patients undergoing surgery, no difference in survival was seen between the preDx and postDx groups (91% vs 89%). The median duration of postoperative ventilation was 7 days and the median length of stay was 36 days for the 66 survivors, with no...Continue Reading

References

Dec 31, 1997·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·Joshua A CopelC S Kleinman
Mar 10, 2001·Circulation·Wayne TworetzkyNorman H Silverman
Dec 11, 2003·The Journal of Thoracic and Cardiovascular Surgery·David C BellingerJane W Newburger
Apr 3, 2004·Pediatrics·Jodi M BartlettJane W Newburger
Apr 28, 2004·The Annals of Thoracic Surgery·Anthony AzakieTom Karl
Feb 14, 2006·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Clifford L CuaPeter C Laussen
Sep 25, 2007·The Annals of Thoracic Surgery·James S TweddellGeorge M Hoffman
Nov 9, 2007·The New England Journal of Medicine·Steven P MillerDaniel B Vigneron
Feb 5, 2008·The Journal of Thoracic and Cardiovascular Surgery·Vladimiro L VidaFrancis Fynn-Thompson
Apr 30, 2008·The Annals of Thoracic Surgery·Jeffrey P JacobsJames A Quintessenza
May 24, 2008·The Annals of Thoracic Surgery·Jenifer A GlatzJames S Tweddell
Jun 7, 2008·The Journal of Pediatrics·Brent M GordonRuey-Kang Chang
Apr 28, 2009·The Journal of Pediatrics·Mark K FriedbergLisa K Hornberger
Feb 19, 2010·Pediatric Cardiology·Allison LeveyIsmee A Williams
May 28, 2010·The New England Journal of Medicine·Richard G OhyePediatric Heart Network Investigators

Citations

Feb 16, 2016·Clinics in Perinatology·Laura SanapoMary T Donofrio
Jul 16, 2013·The Journal of Thoracic and Cardiovascular Surgery·Pirouz ShamszadChristopher J Petit
Sep 25, 2014·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·Lindsay R FreudWayne Tworetzky
Apr 24, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·B J HollandC R Woods
Mar 17, 2015·Frontiers in Pediatrics·Antonio Francesco Corno
Jul 31, 2013·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Hanna K MarkkanenTiina H Ojala
Sep 4, 2013·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Anita Szwast, Jack Rychik
Oct 13, 2015·Revista chilena de pediatría·Gonzalo UrcelayPedro Becker
Apr 20, 2016·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Lami Yeo, Roberto Romero
Mar 23, 2017·American Journal of Medical Genetics. Part a·Martina A SteurerLaura L Jelliffe-Pawlowski
Apr 11, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Silvestre R DuranGirija Natarajan
Feb 19, 2013·Seminars in Cardiothoracic and Vascular Anesthesia·Mark D Twite, Richard J Ing
Aug 30, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mehmet Resit AsogluOzhan M Turan
Sep 19, 2018·Cardiology in the Young·Peter P RoeleveldJohn M Costello
Apr 26, 2014·Circulation·Mary T DonofrioAmerican Heart Association Adults With Congenital Heart Disease Joint Committee of the Council on Cardiovascular Disease in
Aug 20, 2014·Current Opinion in Pediatrics·Stacy A S KillenAnn Kavanaugh-McHugh
Jan 17, 2020·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·Geske S BakLeonardo Pereira
Jul 25, 2015·Current Opinion in Pediatrics·Sarah B ClaussGerard R Martin
Feb 16, 2017·Current Treatment Options in Cardiovascular Medicine·Caroline K Lee
Apr 1, 2018·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Lami YeoRoberto Romero
Dec 30, 2020·Pediatric Cardiology·Melinda BarkhuizenAntonio W D Gavilanes
Jun 27, 2020·The Journal of Pediatrics·Daniel A CastellanosShaine A Morris

Related Concepts

Apgar Score
2D Echocardiography
Palliative Surgery
Antenatal Screening Procedures
Resuscitation Procedure
Retrospective Studies
Incidence Studies
Neonatal Intensive Care
Survival Analysis
Hypoplastic Left Heart Syndrome

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.