Prenatal diagnosis of the fetus with hypoplastic left heart syndrome management and outcome

Herz
Paul M VerheijenErik J Meijboom

Abstract

To review our 13-year experience with prenatally detected hypoplastic left heart syndrome (HLHS) of which management remains controversial. Retrospective study of the management and outcome in all cases of HLHS diagnosed prenatally in a tertiary referral center for pediatric cardiology and cardiac surgery between January 1988 and July 2001. The diagnosis of HLHS was made in 32 fetuses. One mother had two pregnancies associated with HLHS. In 16 cases parents opted for termination of pregnancy and in five for compassionate care. Four fetuses died in utero, and seven patients received a palliative reconstructive Norwood procedure. In seven fetuses, associated anomalies were detected: three chromosomal and structural and four only structural. In six fetuses, other associated intracardiac anomalies were detected. Of seven infants operated, six had no associated anomalies and only one is alive at an age of 17 months. The low percentage of intention to treat among patients in our center (34%) is in accordance with the percentage found in another study from the UK (36.2%), but differs significantly from reported series across the Atlantic (67%). Prenatal diagnosis of the HLHS provides opportunities not only for getting patients in opti...Continue Reading

Citations

Jul 24, 2008·Pediatric Radiology·Laurent Garel
Mar 3, 2006·Expert Review of Cardiovascular Therapy·Omar Khalid, Peter Koenig
Jun 7, 2008·The Journal of Pediatrics·Brent M GordonRuey-Kang Chang
Oct 10, 2003·Prenatal Diagnosis
Feb 16, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S FechnerM Meyer-Wittkopf
Apr 16, 2009·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A GalindoA Mendoza
May 26, 2010·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J RychikM P Johnson
Nov 25, 2004·Pediatric Clinics of North America·Amanda J Shillingford, Gil Wernovsky
Apr 8, 2014·American Journal of Obstetrics and Gynecology·Ray O Bahado-SinghKypros H Nicolaides
Jul 2, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Nihal Sahin-UysalFiliz Yanık
Mar 24, 2018·Pediatric Cardiology·Hisato YagiCecilia W Lo
Aug 27, 2005·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Rebecca H AllenLouise Wilkins Haug
Nov 7, 2019·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Victor Bautista-HernandezPedro J Del Nido

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