PMID: 8598966Mar 1, 1996Paper

Prenatal diagnosis of the RhD fetal blood type on amniotic fluid by polymerase chain reaction

Obstetrics and Gynecology
I B Van den VeyverM R Hughes

Abstract

To assess the accuracy of a molecular assay for the determination of the fetal RhD status on amniotic fluid (AF)samples. Amplification of DNA by polymerase chain reaction of a common sequence of the RhD and CE genes and of a unique sequence of the RhD gene was performed on AF directly or after DNA extraction. Samples of AF obtained from patients undergoing amniocentesis for standard obstetric indications were used for the study. Amplification of DNA was successful on 112 of 114 samples. One hundred four fetuses were found to be RhD positive and eight were found to be RhD negative. Serologic confirmation of the RhD blood type was available on 108 samples and DNA diagnosis was correct in all cases. Polymerase chain reaction can be used to determine accurately the fetal RhD blood type from AF samples.

References

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Citations

Oct 16, 1999·Prenatal Diagnosis·J T Queenan
Aug 19, 2007·Archives of Gynecology and Obstetrics·J C GoebelA Scharf
Aug 1, 1996·Obstetrics and Gynecology·G A DildyK Ward
Dec 1, 1996·Obstetrics and Gynecology·I B Van den Veyver, K J Moise
Aug 14, 2001·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·Y M Lo
Jan 9, 1999·Transfusion Medicine·W A FlegelC Gassner
Nov 29, 2001·Transfusion·W J Judd, UNKNOWN Scientific Section Coordinating Committee of the AABB
Apr 29, 1998·Current Opinion in Obstetrics & Gynecology·I B Van den Veyver, B B Roa
Feb 24, 2001·BJOG : an International Journal of Obstetrics and Gynaecology·B PertlM Adinolfi
May 1, 1997·American Journal of Obstetrics and Gynecology·J YankowitzC P Weiner
Nov 26, 1999·Annals of Medicine·Y M Lo

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