PMID: 8942839Dec 1, 1996Paper

Prenatal diagnosis of triploidy during the second trimester of pregnancy

Obstetrics and Gynecology
E JauniauxK H Nicolaides

Abstract

To analyze the results of prenatal findings and the outcome of triploidy and to organize an efficient approach to prenatal diagnosis during the second trimester. We reviewed 70 cases of triploidy presenting between 13 and 29 weeks' gestation over a 10-year period. Each fetus had at least one measurement below the normal range, and 50 cases (71.4%) presented with asymmetrical growth restriction and normal placental appearance. All cases of triploidy associated with partial mole were diagnosed before 25 weeks. Structural fetal defects were observed antenatally in 65 (92.9%) cases. The most common defects were abnormalities of the hands (52.3%), bilateral cerebral ventriculomegaly (36.9%), heart anomalies (33.8%), and micrognathia (26.2%). The most frequent combination of abnormalities was malformation of the hands and ventriculomegaly. Decreased red blood cell counts and high mean cell volume were found in the 50 cases tested. Vaginal bleeding in the first or second trimester was the most common maternal symptom reported. The major features that should alert the sonographer to the possible diagnosis of triploidy are partial molar changes or severe asymmetrical fetal growth restriction in the presence of an apparently normal place...Continue Reading

References

Aug 1, 1992·Mayo Clinic Proceedings·N M LindorG W Dewald
Nov 1, 1990·American Journal of Obstetrics and Gynecology·E Jauniaux, S Campbell
Jan 1, 1989·Fetal Therapy·K H NicolaidesA J Bellingham
Jan 1, 1995·American Journal of Obstetrics and Gynecology·P KuhnK H Nicolaides
Dec 1, 1993·American Journal of Obstetrics and Gynecology·M A SlatteryW M Hague
Feb 1, 1993·American Journal of Obstetrics and Gynecology·R J SnijdersK H Nicolaides

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Citations

Jan 13, 1999·Prenatal Diagnosis·T K MittalA Jones
Dec 18, 2001·Prenatal Diagnosis·A DanielC Loo
May 1, 2002·Prenatal Diagnosis·Thomas D Shipp, Beryl R Benacerraf
Jan 21, 2003·Prenatal Diagnosis·Rainer GassnerKarl Philipp
Dec 16, 1997·Obstetrics and Gynecology·A RijhsinghaniR A Williamson
Jan 16, 1998·Clinical Obstetrics and Gynecology·S J Gross
Aug 5, 2000·The Australian & New Zealand Journal of Obstetrics & Gynaecology·F Rahimpanah, J Smoleniec
Oct 16, 2009·Journal of Medical Case Reports·Clasien van der HouwenMariëlle van Pampus
Jan 25, 2014·Journal of Assisted Reproduction and Genetics·Mette Warming JoergensenKirstine Kirkegaard
Jan 10, 2008·Taiwanese Journal of Obstetrics & Gynecology·Chih-Ping Chen
Mar 16, 2013·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·L EngelbrechtsenUNKNOWN Danish Fetal Medicine Study Group
Oct 13, 2011·American Journal of Medical Genetics. Part a·Ioana Claudia LakovschekBarbara Ulm
Aug 20, 2015·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Susannah MaxwellPeter O'Leary
Mar 25, 2014·American Journal of Obstetrics and Gynecology·Mette W JoergensenLone Sunde
Oct 7, 2011·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·I AnevM Pillai
Mar 11, 2009·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·G L Stephen, M J Willet
Mar 1, 1997·American Journal of Obstetrics and Gynecology·E JauniauxK H Nicolaides
Jul 27, 1999·Gynecologic Oncology·H MatsuiS Sekiya
May 3, 2016·Prenatal Diagnosis·Yaron ZalelMoshe Bronshtein
Aug 6, 2003·Radiologic Clinics of North America·Nancy E Budorick, Mary K O'Boyle
Jun 3, 2017·Prenatal Diagnosis·Diana MassalskaTomasz Roszkowski
Apr 6, 2004·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M-H BillieuxP Vassilakos
Apr 16, 2015·Clinical and Experimental Reproductive Medicine·Mette Warming JoergensenLone Sunde
May 15, 2007·American Journal of Medical Genetics. Part a·Marco CastoriBruno Dallapiccola
Mar 26, 2005·Prenatal Diagnosis·Tianhua HuangAnne M Summers
Nov 7, 2019·Current Opinion in Obstetrics & Gynecology·Paola QuaresimaElena Greco
Aug 31, 2019·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Paolo CavorettoMichael J Seckl
Feb 17, 2007·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Fionnuala M BreathnachFergal D Malone
Nov 29, 2020·Revista colombiana de obstetricia y ginecología·Andrés Mauricio Camacho-Montaño, Reinaldo Niño-Alba
May 26, 2021·Clinical Genetics·Diana MassalskaTomasz Roszkowski

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