Prenatal dietary choline supplementation decreases the threshold for induction of long-term potentiation in young adult rats

Journal of Neurophysiology
G K PyapaliH S Swartzwelder

Abstract

Choline supplementation during gestation in rats leads to augmentation of spatial memory in adulthood. We hypothesized that prenatal (E12-E17) choline supplementation in the rat would lead to an enhancement of hippocampal synaptic plasticity as assessed by long-term potentiation (LTP) at 3-4 mo of age. LTP was assessed blindly in area CA1 of hippocampal slices with first suprathreshold (above threshold for LTP generation in control slices) theta-burst stimulus trains. The magnitude of potentiation after these stimuli was not different between slices from control and prenatally choline supplemented animals. Next, threshold (reliably leading to LTP generation in control slices) or subthreshold theta-burst stimulus trains were applied to slices from control, prenatally choline-supplemented, and prenatally choline-deprived rats. Threshold level stimulus trains induced LTP in slices from both the control and choline-supplemented rats but not in those from the choline-deficient rats. Subthreshold stimulus trains led to LTP induction in slices from prenatally choline-supplemented rats only. These observations indicate that prenatal dietary manipulation of the amino acid, choline, leads to subsequent significant alterations of LTP indu...Continue Reading

References

Jan 1, 1985·Annals of the New York Academy of Sciences·R T BartusC Flicker
May 1, 1988·Developmental Psychobiology·W H MeckC L Williams
Mar 1, 1986·Journal of Neurobiology·C L SahleyA Gelperin
Feb 1, 1974·Archives of Neurology·D A Drachman, J Leavitt
Aug 12, 1983·Science·J K Blusztajn, R J Wurtman
Nov 9, 1995·Nature·H Eichenbaum
May 1, 1993·Trends in Neurosciences·H Eichenbaum, T Otto
Oct 1, 1994·Journal of Neurophysiology·J M Auerbach, M Segal
Jan 1, 1994·Annual Review of Nutrition·S H Zeisel, J K Blusztajn
May 1, 1993·Neurobiology of Aging·D L DeupreeD A Turner
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Jul 1, 1996·Neurobiology of Aging·G K Pyapali, D A Turner
Dec 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T HollerJ K Blusztajn
Feb 6, 1997·Nature·U Frey, R G Morris
Mar 1, 1997·Behavioural Brain Research·L MolinengoP Ghi

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Citations

Oct 7, 2000·Journal of the American College of Nutrition·S H Zeisel
Dec 3, 2003·Journal of Neurophysiology·Qiang LiH Scott Swartzwelder
Jul 20, 2006·Annual Review of Nutrition·Steven H Zeisel
Mar 28, 2006·The Journal of Pharmacology and Experimental Therapeutics·Manickavasagom Alkondon, Edson X Albuquerque
May 6, 2006·Nutrition Reviews·Steven H Zeisel, Mihai D Niculescu
Aug 14, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Jennifer D ThomasHector D Dominguez
Jan 29, 2011·The Journal of Nutrition·Steven H Zeisel
Nov 24, 2007·Alcoholism, Clinical and Experimental Research·Warren H Meck
Nov 6, 2009·The Journal of Biological Chemistry·Kerry-Ann da CostaSteven H Zeisel
Jan 15, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Jan Krzysztof Blusztajn, Tiffany J Mellott
Aug 7, 2019·Journal of Dietary Supplements·Taylor C WallaceSteven H Zeisel
Mar 14, 2020·Journal of Neurodevelopmental Disorders·Jeffrey R WozniakMichael K Georgieff
Mar 18, 1999·Nutrition Reviews·I P Wauben, P E Wainwright
Jan 13, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tiffany J MellottJan Krzysztof Blusztajn
Aug 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C L YenS H Zeisel
Jul 4, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kerry-Ann da CostaSteven H Zeisel
Aug 3, 2007·Journal of Neuroscience Research·Alexandre E Medina, Thomas E Krahe
Jun 11, 2010·The American Journal of Clinical Nutrition·Leslie M FischerSteven H Zeisel
Feb 1, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tiffany J MellottJan Krzysztof Blusztajn
Jan 10, 2013·World Journal of Diabetes·Shyamasundar SukanyaS Thameem Dheen
Mar 29, 2014·Journal of Neurochemistry·Viktoria FischerAlexei V Egorov
Jan 6, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Torbjörn K NilssonSteven Zeisel
Feb 17, 2018·Journal of the American College of Nutrition·Taylor C Wallace
Apr 26, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mary ResseguieSteven H Zeisel
Jun 2, 2009·Journal of Pharmacological Sciences·Yusuke TozukaKeiji Wada
Dec 25, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yanyan WangSteven H Zeisel
Aug 10, 2017·Nutrients·Jan Krzysztof BlusztajnTiffany J Mellott
Mar 6, 2009·The American Journal of Clinical Nutrition·Steven H Zeisel

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