Prenatal, Early-Life, and Childhood Exposure to Air Pollution and Lung Function: The ALSPAC Cohort.

American Journal of Respiratory and Critical Care Medicine
Yutong CaiPaul Elliott

Abstract

Rationale: Exposure to air pollution during intrauterine development and through childhood may have lasting effects on respiratory health.Objectives: To investigate lung function at ages 8 and 15 years in relation to air pollution exposures during pregnancy, infancy, and childhood in a UK population-based birth cohort.Methods: Individual exposures to source-specific particulate matter ≤10 μm in aerodynamic diameter (PM10) during each trimester, 0-6 months, 7-12 months (1990-1993), and up to age 15 years (1991-2008) were examined in relation to FEV1% predicted and FVC% predicted at ages 8 (n = 5,276) and 15 (n = 3,446) years using linear regression models adjusted for potential confounders. A profile regression model was used to identify sensitive time periods.Measurements and Main Results: We did not find clear evidence of a sensitive exposure period for PM10 from road traffic. At age 8 years, 1 μg/m3 higher exposure during the first trimester was associated with lower FEV1% predicted (-0.826; 95% confidence interval [CI], -1.357 to -0.296) and FVC% predicted (-0.817; 95% CI, -1.357 to -0.276), but similar associations were seen for exposures for other trimesters, 0-6 months, 7-12 months, and 0-7 years. Associations were strong...Continue Reading

References

Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
Nov 27, 2002·The European Respiratory Journal·V NèveM Boulé
Apr 6, 2007·Pharmacology & Therapeutics·Radhika Kajekar
Apr 21, 2007·American Journal of Respiratory and Critical Care Medicine·Rosalba Rojas-MartinezIsabelle Romieu
Dec 20, 2007·Epidemiology·Bente OftedalPer Nafstad
Jul 31, 2010·Paediatric and Perinatal Epidemiology·Wieslaw A JedrychowskiJohn D Spengler
Apr 18, 2012·International Journal of Epidemiology·Abigail FraserDebbie A Lawlor
Apr 18, 2012·International Journal of Epidemiology·Andy BoydGeorge Davey Smith
Oct 30, 2012·American Journal of Respiratory and Critical Care Medicine·Erica S SchultzGöran Pershagen
Oct 1, 2013·Environmental Health Perspectives·Ulrike GehringBert Brunekreef
Jan 24, 2015·Environmental Research·Bing-Fang HwangYungling Leo Lee
Mar 5, 2015·The New England Journal of Medicine·W James GaudermanFrank Gilliland
Jul 15, 2015·The New England Journal of Medicine·Peter LangeJørgen Vestbo
Sep 24, 2015·American Journal of Respiratory and Critical Care Medicine·Erica S SchultzErik Melén
Nov 18, 2015·American Journal of Respiratory and Critical Care Medicine·Mary B RiceDiane R Gold
Mar 20, 2015·Journal of Statistical Software·Silvia LiveraniSylvia Richardson
Oct 30, 2016·Paediatric Respiratory Reviews·Insa KortenPhilipp Latzin
Dec 6, 2017·American Journal of Epidemiology·Ander WilsonBrent A Coull
Mar 31, 2018·Environmental Science & Technology·Michelle PlusquinPaolo Vineis
May 2, 2018·Annals of the American Thoracic Society·Nicolas BougasIsabelle Momas
Jan 12, 2019·American Journal of Respiratory and Critical Care Medicine·Gabriela P PeraltaJudith Garcia-Aymerich
Sep 19, 2019·Nature Communications·Hannelore BovéTim S Nawrot

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Citations

Dec 5, 2020·International Journal of Environmental Research and Public Health·Susanne SteinleJohn W Cherrie
Jun 15, 2021·American Journal of Respiratory and Critical Care Medicine·Erick FornoPaul D Robinson

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