Prenatal EDCs Impair Mate and Odor Preference and Activation of the VMN in Male and Female Rats.

Endocrinology
Morgan E Hernandez ScudderAndrea C Gore

Abstract

Environmental endocrine-disrupting chemicals (EDCs) disrupt hormone-dependent biological processes. We examined how prenatal exposure to EDCs act in a sex-specific manner to disrupt social and olfactory behaviors in adulthood and underlying neurobiological mechanisms. Pregnant rat dams were injected daily from embryonic day 8 to 18 with 1 mg/kg Aroclor 1221 (A1221), 1 mg/kg vinclozolin, or the vehicle (6% DMSO in sesame oil). A1221 is a mixture of polychlorinated biphenyls (weakly estrogenic) while vinclozolin is a fungicide (anti-androgenic). Adult male offspring exposed to A1221 or vinclozolin, and females exposed to A1221, had impaired mate preference behavior when given a choice between 2 opposite-sex rats that differed by hormone status. A similar pattern of impairment was observed in an odor preference test for urine-soaked filter paper from the same rat groups. A habituation/dishabituation test revealed that all rats had normal odor discrimination ability. Because of the importance of the ventrolateral portion of the ventromedial nucleus (VMNvl) in mate choice, expression of the immediate early gene product Fos was measured, along with its co-expression in estrogen receptor alpha (ERα) cells. A1221 females with impaired ...Continue Reading

References

Jun 1, 1975·Physiology & Behavior·M Eliasson, B J Meyerson
Jan 1, 1986·Physiology & Behavior·D A Edwards, L C Einhorn
Apr 1, 1970·Physiology & Behavior·J W Scott, D W Pfaff
Jan 1, 1984·Annual Review of Neuroscience·A P Arnold, R A Gorski
Jun 1, 1982·Physiology & Behavior·G T TaylorD Regan
Aug 1, 1980·Developmental Medicine and Child Neurology·P M Rodier
May 1, 1994·Physiology & Behavior·J Vega MatuszczykK Larsson
Sep 18, 1995·The Journal of Comparative Neurology·N S CanterasL W Swanson
Jul 2, 2003·Physiology & Behavior·A K HotchkissL E Gray
Aug 23, 2003·Endocrinology·Tandra R ChakrabortyAndrea C Gore
Aug 25, 2004·Hormones and Behavior·Kai XiaoYasuo Sakuma
Apr 6, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·D N R VeeramachaneniK-Y F Pau
Feb 6, 2007·Hormones and Behavior·Rebecca M SteinbergAndrea C Gore
Mar 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·David CrewsMichael K Skinner
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Karen A KiddRobert W Flick
Jan 25, 2008·The European Journal of Neuroscience·Sylvie PiermanJulie Bakker
Sep 2, 2008·Physiology & Behavior·Barbara NofreyAaron Ettenberg
Sep 30, 2010·Regulatory Toxicology and Pharmacology : RTP·Steffen SchneiderBennard van Ravenzwaay

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Citations

May 1, 2021·Journal of the Endocrine Society·Morgan E Hernandez ScudderAndrea C Gore
May 22, 2021·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Michael P ReillyAndrea C Gore

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