Prenatal Endotoxin Exposure Induces Fetal and Neonatal Renal Inflammation via Innate and Th1 Immune Activation in Preterm Pigs.

Frontiers in Immunology
Tik MukDuc Ninh Nguyen

Abstract

Chorioamnionitis (CA) predisposes to preterm birth and affects the fetal mucosal surfaces (i.e., gut, lungs, and skin) via intra-amniotic (IA) inflammation, thereby accentuating the proinflammatory status in newborn preterm infants. It is not known if CA may affect more distant organs, such as the kidneys, before and after preterm birth. Using preterm pigs as a model for preterm infants, we investigated the impact of CA on fetal and neonatal renal status and underlying mechanisms. Fetal pigs received an IA dose of lipopolysaccharide (LPS), were delivered preterm by cesarean section 3 days later (90% gestation), and compared with controls (CON) at birth and at postnatal day 5. Plasma proteome and inflammatory targets in kidney tissues were evaluated. IA LPS-exposed pigs showed inflammation of fetal membranes, higher fetal plasma creatinine, and neonatal urinary microalbumin levels, indicating renal dysfunction. At birth, plasma proteomics revealed LPS effects on proteins associated with renal inflammation (up-regulated LRG1, down-regulated ICA, and ACE). Kidney tissues of LPS pigs at birth also showed increased levels of kidney injury markers (LRG1, KIM1, NGLA, HIF1A, and CASP3), elevated molecular traits related to innate immun...Continue Reading

References

Oct 1, 1988·American Journal of Hypertension·B M BrennerS Anderson
Jan 1, 1984·Annals of the New York Academy of Sciences·T D DuBose
Oct 1, 1982·The American Journal of Physiology·D C Dobyan, R E Bulger
Jul 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H S Mackenzie, B M Brenner
May 18, 2000·The New England Journal of Medicine·R L GoldenbergW W Andrews
Jun 8, 2002·Veterinary Immunology and Immunopathology·Ilja TrebichavskýYasuyuki Mori
Jun 26, 2002·Kidney International·Won K HanJoseph V Bonventre
Jul 17, 2004·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Maria M RodríguezGastón E Zilleruelo
Oct 26, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·L CataldiL Cuzzolin
Dec 14, 2005·Animal Biotechnology·Lawrence SchookDouglas Smith
Mar 4, 2006·Circulation Research·Ursula Danilczyk, Josef M Penninger
Jul 1, 2006·Kidney International·M C Chappel, C M Ferrario
Dec 17, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·David J AskenaziStuart L Goldstein
Sep 18, 2009·American Journal of Physiology. Renal Physiology·Lina GubhajuM Jane Black
Jun 24, 2010·Clinics in Perinatology·Alan T N Tita, William W Andrews
Jun 24, 2010·Protein Science : a Publication of the Protein Society·Brian E EckenrothStephen J Everse
Dec 24, 2010·Pediatric Research·Rajesh KoralkarDavid Askenazi
Apr 19, 2011·Journal of Pediatric Surgery·Samir K GadepalliGeorge B Mychaliska
May 20, 2011·American Journal of Physiology. Renal Physiology·Robert GalinskyGraeme R Polglase
Jan 25, 2012·The American Journal of Medicine·Tobias BreidthardtChristian Müller
Mar 1, 2012·Inflammatory Bowel Diseases·Satoshi SeradaTetsuji Naka
May 29, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Nauman Rauf KhanSaima Chaudhry
Aug 15, 2012·Nephron. Clinical Practice·Arif Khwaja
Mar 28, 2013·Journal of Pregnancy·Robert GalinskyTimothy J M Moss
Mar 1, 2011·Toxicological Research·Tae-Gyu Nam
Jan 7, 2014·Seminars in Reproductive Medicine·Suhas G KallapurClaire A Chougnet
Jan 25, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tim G A M WolfsSuhas G Kallapur
Jun 1, 2014·The Lancet Infectious Diseases·Tobias StrunkOfer Levy
Oct 5, 2014·Clinical Journal of the American Society of Nephrology : CJASN·J Bryan CarmodyJennifer R Charlton
Oct 25, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Per T SangildDouglas Burrin
Jan 16, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Di ZhongXianfeng Li
Jan 24, 2015·CNS & Neurological Disorders Drug Targets·Eveline StrackxAntonio W D Gavilanes
Apr 22, 2015·Journal of Enzyme Inhibition and Medicinal Chemistry·Hulya GocerClaudiu T Supuran

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Datasets Mentioned

BETA
PXD016013

Methods Mentioned

BETA
cesarean section
MDA
acetylation
ELISA

Software Mentioned

Image J
Andromeda
lme4
ClueGO
R
MaxQuant
ImageJ
Cytoscape

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