Prenatal exercise reprograms the development of hypertension progress and improves vascular health in SHR offspring.

Vascular Pharmacology
Shanshan LiLijun Shi

Abstract

Upregulation of L-type voltage-gated Ca2+ (CaV1.2) channel in the arterial myocytes is a hallmark feature of hypertension. However, whether maternal exercise during pregnancy has a sustained beneficial effect on the offspring of spontaneously hypertensive rats (SHRs) through epigenetic regulation of CaV1.2 channel is largely unknown. Pregnant SHRs and Wistar-Kyoto rats were subjected to swimming and the vascular molecular and functional properties of male offspring were evaluated at embryonic (E) 20.5 day, 3 months (3 M), and 6 months (6 M). Exercise during pregnancy significantly decreased the resting blood pressure at 3 M but not 6 M in the offspring of SHR. Prenatal exercise significantly reduced the cardiovascular reactivity, the contribution of CaV1.2 channel to the vascular tone, and the whole-cell current density of CaV1.2 channel in both 3 M and 6 M offspring of SHR. Moreover, maternal exercise triggered hypermethylation of the promoter region of the CaV1.2 α1C gene (CACNA1C), with a concomitant decrease in its protein and mRNA expressions in SHR offspring at E20.5, 3 M, and 6 M. Tissue culture experiments further confirmed that 5-Aza-2'-deoxycytidine increased the structure and functional expression of CaV1.2 channel b...Continue Reading

References

Aug 4, 1990·BMJ : British Medical Journal·D J BarkerS J Simmonds
Aug 1, 1996·Comparative Biochemistry and Physiology. Part A, Physiology·S C Langley-Evans
Feb 29, 2000·American Journal of Obstetrics and Gynecology·J F Clapp, W Kiess
Mar 31, 2000·Clinics in Sports Medicine·J F Clapp
Mar 29, 2001·São Paulo Medical Journal = Revista Paulista De Medicina·J C PeraçoliR J da Silva Franco
Sep 11, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·James F Clapp
Nov 10, 2004·Diabetes Research and Clinical Practice·Jennifer C DempseyMichelle A Williams
Mar 31, 2005·The Journal of Clinical Endocrinology and Metabolism·Joy C BuntArline D Salbe
Jan 24, 2006·Vascular Pharmacology·Swapnil SonkusareNancy J Rusch
May 28, 2008·Gender Medicine·Daniela GrigoreBarbara T Alexander
Jun 3, 2009·Nature Reviews. Endocrinology·Peter D GluckmanAlan S Beedle
Jun 23, 2009·Trends in Pharmacological Sciences·Michael A HillIsmail Laher
Oct 15, 2010·Nature Biotechnology·Anna Portela, Manel Esteller
Jul 13, 2011·Cold Spring Harbor Perspectives in Biology·William A Catterall
Apr 18, 2012·Fetal and Pediatric Pathology·Débora Tavares de Resende e Silva AbateMarlene Antônia Reis
Aug 17, 2012·Medicine and Science in Sports and Exercise·Lanay M MuddJames M Pivarnik
Jul 17, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Andrew D KaneDino A Giussani
Oct 26, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A SoubryC Hoyo
Apr 8, 2014·Medical Hypotheses·Júlia M SantosSandra A Benite-Ribeiro
May 17, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Anne Brunet, Shelley L Berger
Sep 25, 2014·Acta Cirúrgica Brasileira·Renato RochaKleber Eduardo de Campos
Nov 29, 2014·Epigenomics·Thomas E W Chalk, William M Brown
Dec 5, 2014·Journal of Developmental Origins of Health and Disease·A C HaugenJ J Heindel
Apr 18, 2015·BMC Pregnancy and Childbirth·Stamatis P MourtakosLabros S Sidossis
Apr 24, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yu ChenLijun Shi
Jul 5, 2015·Life Sciences·Kana MaruyamaKazumasa Shinozuka
Dec 26, 2015·American Journal of Obstetrics and Gynecology·Ruben BarakatMichelle F Mottola
Dec 30, 2015·International Journal of Molecular Sciences·You-Lin Tain, Jaap A Joles
Feb 21, 2016·Pharmacology & Therapeutics·Susumu OhyaKatsuhiko Muraki

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