Prenatal exposure to allergen, DNA methylation, and allergy in grandoffspring mice.

Allergy
M NiedzwieckiR L Miller

Abstract

Prenatal allergen exposure has been linked to both induction and protection of allergic sensitization in offspring. We hypothesized that prenatal exposure of mice (F0) to Aspergillus fumigatus (A. fumigatus) would be associated with decreased immunoglobulin (Ig) E and airway eosinophilia and alterations in CpG methylation of T-helper genes in third-generation mice (F2). Female BALB/c mice were sensitized to A. fumigatus (62.5, 125, 1250 μg, or saline) and re-exposed to the same dose on days 7 and 14 (early) or days 12 and 17 (late) gestation. Grandoffspring were treated with A. fumigatus (62.5 μg) at 9 weeks. IgE, IgG(1) , and IgG(2a) levels and cell counts from bronchoalveolar lavage fluid were determined. Lung DNA was pyrosequenced at multiple sites in the interferon (IFN)-γ and interleukin (IL)-4 promoters. Grandoffspring of mothers dosed with 1250 μg early during pregnancy developed increased airway eosinophilia (P < 0.05). Grandoffspring of mothers dosed late in pregnancy developed lower IgE (P < 0.05) and airway eosinophilia (P < 0.05). Grandoffspring of mothers dosed early had lower methylation at IL-4 CpG(-408) and CpG(-393) compared to late dosed mice (P < 0.005 across all doses). Few correlations were found between me...Continue Reading

References

Dec 31, 1997·Clinical and Experimental Immunology·C IshiharaN Koya
Nov 7, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G DevereuxR N Barker
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kaoru HamadaLester Kobzik
Mar 15, 2005·Current Opinion in Allergy and Clinical Immunology·P Ly NgocJuan C Celedón
Nov 29, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jinming LiuRachel L Miller
Jan 12, 2008·American Journal of Respiratory and Critical Care Medicine·Rachel L Miller, Shuk-Mei Ho
Sep 20, 2008·The Journal of Clinical Investigation·John W HollingsworthDavid A Schwartz
Dec 5, 2008·Archives of Disease in Childhood·S E HåbergW Nystad
Apr 14, 2009·The Journal of Allergy and Clinical Immunology·Junenette L PetersRosalind J Wright
Jun 6, 2009·American Journal of Respiratory and Critical Care Medicine·Carrie V BretonFrank D Gilliland
Jul 2, 2009·Yonsei Medical Journal·Choong-Gu LeeSin-Hyeog Im
Jul 25, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christopher J GamperJonathan D Powell
Aug 7, 2009·Human Molecular Genetics·Elmar W TobiBastiaan T Heijmans
Nov 3, 2009·American Journal of Epidemiology·Melissa J WhitrowMichael J Davies
Feb 2, 2010·American Journal of Respiratory Cell and Molecular Biology·Alexey V Fedulov, Lester Kobzik
Mar 31, 2010·American Journal of Obstetrics and Gynecology·Yevgeniya PozharnyMen-Jean Lee
May 13, 2010·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Lin CorsonRachel L Miller
Jul 9, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Caroline E W HerrIrva Hertz-Picciotto
Aug 4, 2010·Environmental Health : a Global Access Science Source·Caroline E W HerrIrva Hertz-Picciotto
Oct 6, 2010·The Journal of Allergy and Clinical Immunology·Kari NadeauIra Tager
Jan 25, 2011·Reproductive Toxicology·Frederica Perera, Julie Herbstman

❮ Previous
Next ❯

Citations

Feb 7, 2013·Current Opinion in Allergy and Clinical Immunology·Junenette L PetersMegan Sandel
Jul 10, 2014·Pulmonary Circulation·Gabriele GrunigSung-Hyun Park
Mar 16, 2013·Autism Research : Official Journal of the International Society for Autism Research·Keerthi Thirtamara RajamaniHoward Gu
Jan 22, 2014·Environmental and Molecular Mutagenesis·Robert Ys ChengWan-Yee Tang
Jun 9, 2015·Clinical Epigenetics·Susanne Krauss-EtschmannMachteld N Hylkema
Feb 14, 2017·The Journal of Allergy and Clinical Immunology·Phoebe K RichgelsIan P Lewkowich
Feb 16, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R J BertelsenC Svanes
Apr 21, 2018·Annals of the American Thoracic Society·Rachel L Miller, Jennifer Lawrence
Mar 27, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bethany WinansB Paige Lawrence
Aug 6, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Virender K RehanJohn S Torday
Mar 7, 2021·Nutrients·Nathalie AcevedoBetty C A M van Esch
Sep 9, 2021·Environmental Health Perspectives·Kyung Hwa JungStephanie Lovinsky-Desir

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Related Papers

American Journal of Respiratory Cell and Molecular Biology
Alexey V Fedulov, Lester Kobzik
The Journal of Asthma : Official Journal of the Association for the Care of Asthma
Prachi GuptaSurendra Kumar Bansal
Biochimica Et Biophysica Acta
W S Fred Wong, Khai Pang Leong
© 2021 Meta ULC. All rights reserved