Prenatal exposure to bisphenol A alters mouse fetal pancreatic morphology and islet composition

Hormone Molecular Biology and Clinical Investigation
Rebecca WhiteheadKaiping Yang

Abstract

Exposure to bisphenol A (BPA), an endocrine disrupting chemical, during gestation is associated with a variety of metabolic dysfunctions in adulthood, including hyperinsulinemia, glucose intolerance and insulin resistance. These modifications in glucose homeostasis largely stem from alterations in pancreatic function. However, the effects of BPA on the fetal pancreas have never been explored. The present study addressed this important question by examining the effects of prenatal BPA exposure on the mouse fetal pancreatic development. Pregnant mice were fed a BPA diet (25 mg BPA/kg diet) from embryonic day 7.5 (E7.5) to E18.5. At E18.5, fetal pancreata were collected and analyzed for morphological changes in the endocrine pancreas such as islet size, number and β and α cell distribution. We showed that BPA exposed fetal pancreata had a greater number of islet-cell clusters (ICCs; <300 μm(2); p<0.05) compared with controls. Furthermore, immunohistochemical analysis revealed that prenatal BPA exposure increased both glucagon expression in islets and the numbers of glucagon-expressing islet-cell clusters (p<0.05). Considering that ICCs represent the initial stages of islet development in the fetal pancreas, our findings suggest th...Continue Reading

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