Prenatal exposure to bisphenol A alters the transcriptome-interactome profiles of genes associated with Alzheimer's disease in the offspring hippocampus.

Scientific Reports
Suporn SukjamnongTewarit Sarachana

Abstract

Our recent study revealed that prenatal exposure to bisphenol A (BPA) disrupted the transcriptome profiles of genes in the offspring hippocampus. In addition to genes linked to autism, several genes associated with Alzheimer's disease (AD) were found to be differentially expressed, although the association between BPA-responsive genes and AD-related genes has not been thoroughly investigated. Here, we demonstrated that in utero BPA exposure also disrupted the transcriptome profiles of genes associated with neuroinflammation and AD in the hippocampus. The level of NF-κB protein and its AD-related target gene Bace1 were significantly increased in the offspring hippocampus in a sex-dependent manner. Quantitative RT-PCR analysis also showed an increase in the expression of Tnf gene. Moreover, the reanalysis of transcriptome profiling data from several previously published BPA studies consistently showed that BPA-responsive genes were significantly associated with top AD candidate genes. The findings from this study suggest that maternal BPA exposure may increase AD risk in offspring by dysregulating genes associated with AD neuropathology and inflammation and reveal a possible relationship between AD and autism, which are linked to...Continue Reading

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Citations

Jan 5, 2021·Journal of Biochemical and Molecular Toxicology·Tauqeerunnisa Syeda, Jason R Cannon
Jan 10, 2021·Animals : an Open Access Journal From MDPI·Krystyna Makowska, Sławomir Gonkowski

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Datasets Mentioned

BETA
GSE140298

Methods Mentioned

BETA
RNA-seq
protein assay

Software Mentioned

Ingenuity Pathway Analysis
Ingenuity Pathway Analysis ( IPA )
Primer3
RSEM
ImageJ
SPSS
IPA
Multiple Experiment Viewer ( MeV )
Bowtie

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