Abstract
Exemption was granted by the Stockholm Convention in 2004 for use of DDT by indoor residual spraying (IRS) as a malaria vector control. South Africa endorsed the use of DDT in its Malaria Control Programmes in malaria endemic regions and IRS remains a primary method of controlling malaria transmitting mosquitoes in this country. This study examines the impact of IRS on the levels of DDT and its metabolites in maternal blood of delivering women as a measure of prenatal exposure. We report on the concentrations of DDT and its metabolites (p,p'- DDE, p,p'-DDT, o,p'-DDE, o,p'-DDD, p,p'-DDD, and o,p'-DDT) in maternal plasma of 255 delivering women residing in three sites along Indian Ocean, namely in malaria endemic where IRS takes place, low risk and non-malaria sites. Concentrations of measured compounds were found to be significantly higher in the malaria endemic site (p=0.0001): the geometric mean concentration (95% confidence intervals; n=91) for o,p'-DDE was 9 ng/g lipids (7-10); for p,p'-DDE, 3840 ng/g lipids (3008-4902); for o,p'-DDD, 8 ng/g lipids (6-9); for p,p'-DDD, 26 ng/g lipids (20-32); for o,p'-DDT, 168 ng/g lipids (127-221) and for p,p'-DDT, 2194 ng/g lipids (1706-2823). These compounds were also detected in women re...Continue Reading
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