Prenatal Exposure to Endocrine-disrupting Chemicals in Relation to Autism Spectrum Disorder and Intellectual Disability

Epidemiology
Ghassan B HamraLisa A Croen

Abstract

Exposure to endocrine disruptors is unavoidable. Many such compounds are suspected to impact neurologic development of children, but most studies conducted have considered effects of individual chemicals in isolation. Because exposures co-occur, it is important to consider their health impacts in a single regression framework. We applied Bayesian statistical tools (including shared mean and mixture priors for 25 unique chemicals) to study independent associations of endocrine disruptor biomarkers with autism spectrum disorder (ASD) (n = 491) and intellectual disability (n = 155), compared with 373 general population controls, in the Early Markers for Autism study. We measured biomarkers in maternal serum collected and stored from midpregnancy and considered them individually or as a class (i.e., summed polychlorinated biphenyls). We adjusted all models for original matching factors (child sex and month and year of birth), maternal age, maternal race/ethnicity, parity, and maternal education at the time samples were collected. We estimated the change in the odds of ASD or intellectual disability per 1 SD increase in the z-score of measured biomarker concentration for each chemical. Odds of ASD and intellectual disability did not...Continue Reading

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Citations

Jul 1, 2020·Reviews on Environmental Health·Ann M VuongAimin Chen
Feb 7, 2021·International Journal of Environmental Research and Public Health·Ghassan B HamraCraig Newschaffer
May 13, 2021·Journal of Autism and Developmental Disorders·Li WangYing Wang
Jun 3, 2021·International Journal of Environmental Research and Public Health·Judit Biosca-BrullMaria Teresa Colomina

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