Prenatal exposure to ethanol during late gestation facilitates operant self-administration of the drug in 5-day-old rats

Alcohol
R Sebastián Miranda-MoralesNorman E Spear

Abstract

Prenatal ethanol exposure modifies postnatal affinity to the drug, increasing the probability of ethanol use and abuse. The present study tested developing rats (5-day-old) in a novel operant technique to assess the degree of ethanol self-administration as a result of prenatal exposure to low ethanol doses during late gestation. On a single occasion during each of gestational days 17-20, pregnant rats were intragastrically administered ethanol 1 g/kg, or water (vehicle). On postnatal day 5, pups were tested on a novel operant conditioning procedure in which they learned to touch a sensor to obtain 0.1% saccharin, 3% ethanol, or 5% ethanol. Immediately after a 15-min training session, a 6-min extinction session was given in which operant behavior had no consequence. Pups were positioned on a smooth surface and had access to a touch-sensitive sensor. Physical contact with the sensor activated an infusion pump, which served to deliver an intraoral solution as reinforcement (Paired group). A Yoked control animal evaluated at the same time received the reinforcer when its corresponding Paired pup touched the sensor. Operant behavior to gain access to 3% ethanol was facilitated by prenatal exposure to ethanol during late gestation. I...Continue Reading

References

Jan 1, 1980·Psychological Bulletin·E L Abel
Oct 1, 1980·Pharmacology, Biochemistry, and Behavior·N AnandamJ M Stern
Feb 3, 2000·Alcoholism, Clinical and Experimental Research·P AbateJ C Molina
Aug 16, 2001·Alcoholism, Clinical and Experimental Research·P AbateJ C Molina
Apr 16, 2003·Archives of General Psychiatry·John S BaerAnn P Streissguth
Jun 25, 2005·Alcoholism, Clinical and Experimental Research·Norman E Spear, Juan C Molina
Nov 1, 2005·Pharmacology, Biochemistry, and Behavior·Carlos Arias, M Gabriela Chotro
Jan 26, 2006·Alcoholism, Clinical and Experimental Research·Michael E NizhnikovNorman E Spear
Oct 3, 2006·Neuroscience and Biobehavioral Reviews·M Gabriela ChotroGiovanni Laviola
Mar 28, 2007·Alcoholism, Clinical and Experimental Research·Eric M TruxellNorman E Spear
Mar 28, 2008·Alcoholism, Clinical and Experimental Research·Kelly A BordnerNorman E Spear
Jun 24, 2008·Pharmacology, Biochemistry, and Behavior·Luciano Federico PonceJuan Carlos Molina
May 12, 2009·Neuroscience and Biobehavioral Reviews·Ricardo M PautassiNorman E Spear
Sep 2, 2009·Alcoholism, Clinical and Experimental Research·Samanta M MarchJuan Carlos Molina
Jul 14, 2011·Psychopharmacology·Roberto Sebastián Miranda-MoralesPaula Abate
Jul 14, 2012·Behavioural Brain Research·Roberto Sebastián Miranda-MoralesPaula Abate

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Citations

Jan 21, 2015·Physiology & Behavior·John H HanniganVirginia Delaney-Black
Sep 3, 2014·Physiology & Behavior·Ricardo Marcos PautassiMichael Nizhnikov
Oct 26, 2016·Pharmacology, Biochemistry, and Behavior·Stefania CastelloJuan Carlos Molina
Feb 16, 2017·Frontiers in Behavioral Neuroscience·Mirari GaztañagaM Gabriela Chotro
Mar 12, 2017·Environmental Health : a Global Access Science Source·Lisa G GallagherAnn Aschengrau
Mar 27, 2020·Frontiers in Behavioral Neuroscience·Roberto Sebastián Miranda-MoralesJuan Carlos Molina
Apr 6, 2017·Frontiers in Behavioral Neuroscience·María B AcevedoJuan C Molina
May 4, 2017·Psychonomic Bulletin & Review·Vanessa AndréVirginie Durier
Jul 21, 2021·Biological Psychiatry·Sebastiano Bariselli, David M Lovinger

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