Prenatal exposure to gestational diabetes mellitus increases developmental defects in the enamel of offspring

PloS One
Tawana PasconMarilza V C Rudge

Abstract

Gestational diabetes mellitus (GDM) is associated with short- and long-term maternal and perinatal repercussions. Our objective was to evaluate the long-term consequences of intrauterine exposure to hyperglycemia on Developmental Defects of Enamel (DDE) in offspring. Overall, 50 children of women with GDM and 250 children of normoglycemic women participated, the latter serving as controls. Children were examined at the age between 3 and 12 years. In addition to physical examination, two independent observers examined and rated photographs to identify specific types of DDE in a blinded fashion. Among offspring of mothers with GDM, rates of DDE (all types combined) and hypoplasia (specific type) were significantly higher (p<0.001, p = 0.04), in comparison to offspring of normoglycemic mothers. Considering only the affected teeth (1060 in GDM category; 5499 in controls), rates of DDE (all types combined) were significantly higher for total teeth (p <0.001) and deciduous teeth (p<0.001), but not permanent teeth. In specific types of DDE involving deciduous teeth, rates of demarcate opacity were significantly higher (p<0.001; canine and 2nd mandibular molars) and hypoplasia (p <0.001; 2nd maxillary molars and 2nd mandibular molars)....Continue Reading

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Citations

Nov 21, 2020·Journal of Public Health Dentistry·Daniele Gomes DouradoMarina de Deus Moura de Lima
Aug 21, 2021·Clinical Oral Investigations·Laura Jordana Santos LimaMaria Eliza Consolação Soares

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Methods Mentioned

BETA
optical microscopy
scanning electron microscopy

Software Mentioned

SPSS

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