Prenatal exposure to methadone or buprenorphine and long-term outcomes: A meta-analysis.

Early Human Development
Jannike Mørch AndersenEgil Nygaard

Abstract

To combine meta-analyses of multiple long-term outcomes in children prenatally exposed to methadone or buprenorphine through their mothers' Opioid maintenance therapy (OMT) with a systematic review of similar outcomes in experimental animals. The Medline, Embase, Web of Science, CINAHL, Cochrane and Epistemonikos databases were searched through August 30, 2018. Clinical studies measuring effects on cognitive, behavioral or visual outcomes in 3 months or older children prenatally exposed to OMT and control group(s) were included for meta-analyses. Experimental animal studies with similar exposures and outcomes were included in a systematic review. The three authors independently performed abstract screenings and full-text reviews, and extracted the data. One author performed the meta-analyses. The pooled results of the meta-analyses showed worse cognitive, psychomotor, behavioral, attentional and executive functioning, and affected vision in children born to mothers who were in OMT during pregnancy compared to children without prenatal drug exposure (overall effect size = 0.49, 95% confidence interval = 0.38, 0.59, p < 0.00001). Many of the experimental animal studies showed impaired outcomes after prenatal exposure to methadone...Continue Reading

References

Jun 1, 1979·Pharmacology, Biochemistry, and Behavior·I S ZagonC I Thompson
May 1, 1979·Pharmacology, Biochemistry, and Behavior·I S ZagonC I Thompson
Nov 1, 1976·The Journal of Pediatrics·M E StraussJ C Stryker
Sep 1, 1990·Journal of Child Psychology and Psychiatry, and Allied Disciplines·A van Baar
Jan 1, 1989·Annals of the New York Academy of Sciences·G S Wilson
Jan 1, 1988·Addictive Behaviors·D D Davis, D I Templer
Jul 1, 1987·Neurotoxicology and Teratology·K Kaltenbach, L P Finnegan
Aug 1, 1986·The International Journal of the Addictions·P S Bauman, S A Levine
Jun 1, 1985·Pharmacology, Biochemistry, and Behavior·J R Hovious, M A Peters
Nov 17, 1972·Science·Z SteinF Marolla
Apr 1, 1984·The International Journal of the Addictions·F Suffet, R Brotman
Jan 1, 1980·The International Journal of Neuroscience·P R Freeman
Sep 14, 1981·Life Sciences·I S Zagon, P J McLaughlin
Jun 1, 1980·Perceptual and Motor Skills·S Van WagonerD Lasky
Dec 1, 1994·Developmental Medicine and Child Neurology·A van Baar, B M de Graaff
Dec 1, 1996·Pharmacology, Biochemistry, and Behavior·D E HutchingsA C Zmitrovich
Jul 18, 2003·Journal of Substance Abuse Treatment·Jason LutyJenny Bearn
Aug 31, 2007·Early Human Development·Rod W HuntHeather E Jeffery
Sep 5, 2008·The American Journal on Addictions·Hendrée E JonesMichelle Tuten
Sep 16, 2009·Neurotoxicology and Teratology·Justine N WhithamAndrea L Gordon
Apr 22, 2010·Journal of Addictive Diseases·Barry M Lester, Linda L Lagasse
Apr 12, 2011·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Carolien Konijnenberg, Annika Melinder
Aug 27, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·John J McCarthy
Aug 30, 2011·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Suzanne WongUNKNOWN Society of Obstetricians and Gynecologists of Canada
Jan 10, 2012·Current Opinion in Pediatrics·Lauren M Jansson, Martha Velez
May 2, 2012·JAMA : the Journal of the American Medical Association·Stephen W PatrickMatthew M Davis
May 29, 2012·Pharmacology, Biochemistry, and Behavior·Felicity M DalyLianne J Woodward
Jun 19, 2012·Pediatric Neurology·Kristine B WalhovdLianne J Woodward
Aug 1, 2012·Physiological Research·R Šlamberová
Oct 16, 2012·Development and Psychopathology·Catherine MonkFrances A Champagne
Jan 15, 2013·Clinical Obstetrics and Gynecology·Beth A LoganMarie J Hayes
Feb 27, 2013·Pediatrics·Marylou BehnkeUNKNOWN Committee on Fetus and Newborn
Apr 16, 2013·Progress in Neurobiology·Bridgette D SempleLinda J Noble-Haeusslein
Aug 27, 2013·Clinics in Perinatology·Todd J StanhopeCarl Rose
Nov 20, 2013·The British Journal of Ophthalmology·Laura McGloneHelen Mactier
Dec 11, 2013·Toxicology Letters·Chih-Cheng WuChun-Jung Chen

❮ Previous
Next ❯

Citations

Jun 3, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Mette KongstorpJannike Mørch Andersen
Jan 9, 2021·Journal of Neuroradiology. Journal De Neuroradiologie·Rupa RadhakrishnanSenthilkumar Sadhasivam
Mar 7, 2021·Children·Jaylene ShannonStacy Blythe
Oct 17, 2020·Journal of Neuroradiology. Journal De Neuroradiologie·Rupa RadhakrishnanSenthilkumar Sadhasivam
May 27, 2021·Scandinavian Journal of Psychology·Konijnenberg Carolien, Melinder Annika
Jun 12, 2021·Neurotoxicology and Teratology·Madelyn H LabellaMary Dozier
Aug 14, 2021·Developmental Cognitive Neuroscience·Stephanie L MerharWeili Lin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence
Carolien Konijnenberg, Annika Melinder
The Journal of Pharmacology and Experimental Therapeutics
Mette KongstorpJannike Mørch Andersen
© 2021 Meta ULC. All rights reserved