Prenatal exposure to organochlorine compounds and neuropsychological development up to two years of life

Environment International
Joan FornsJesús Ibarluzea

Abstract

Polychlorinated biphenyls (PCB), hexachlorobenzene (HCB), and dichlorodiphenyl dichloroethylene (pp'DDE) are persistent, bioaccumulative, and toxic environmental pollutants with potential neurotoxic effects. Despite a growing body of studies investigating the health effects associated with these compounds, their specific effects on early neuropsychological development remain unclear. We investigated such neuropsychological effects in a population-based birth cohort based in three regions in Spain (Sabadell, Gipuzkoa, and Valencia) derived from the INMA [Environment and Childhood] Project. The main analyses in this report were based on 1391 mother-child pairs with complete information on maternal levels of organochlorine compounds and child neuropsychological assessment (Bayley Scales of Infant Development) at age 14 months. We found that prenatal PCB exposure, particularly to congeners 138 and 153, resulted in impairment of psychomotor development (coefficient=-1.24, 95% confidence interval=-2.41, -0.07), but found no evidence for effects on cognitive development. Prenatal exposure to pp'DDE or HCB was not associated with early neuropsychological development. The negative effects of exposure to PCBs on early psychomotor develop...Continue Reading

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Citations

Apr 18, 2013·Journal of Exposure Science & Environmental Epidemiology·Janet A DiPietroDana Boyd Barr
Jun 23, 2015·International Journal of Hygiene and Environmental Health·Mireia GasconMartine Vrijheid
Aug 5, 2014·Environmental Research·Nadia VilahurJordi Sunyer
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May 3, 2014·Environmental Health Perspectives·Esther VizcainoAdonina Tardón
Jan 2, 2021·Environmental Research·Krista ChristensenGeniece M Lehmann
Apr 22, 2021·Journal of Hazardous Materials·Christian CarrizosaMaria-Jose Lopez-Espinosa

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