PMID: 20640275Aug 5, 2010Paper

Prenatal exposure to organochlorine pesticides and cryptorchidism

Ciência & saúde coletiva
Lília Patrícia Bustamante MontesArlette García Jañas

Abstract

Fetuses and children are more susceptible to the effects of environmental toxins. The objective of this article is to determine the levels of organochlorine pesticides (HCB, ss-HCH, pp'DDT, op'DDT and pp'DDE) in the serum lipids of mothers of newborns with cryptorchidism and compare the levels to a control group of mothers of newborns with descended testicles. The cases were composed of newborns with cryptorchidism (n=41), and the controls (n=41) newborns with descended testicles. Blood samples from both groups of mothers were used to determine the organochlorine pesticide levels. Cryptorchidism was diagnosed at birth by a neonatologist. The results showed that the organochlorine pesticide residues were found in the serum lipids of both groups of mothers. The median serum lipid levels (mgkg-1 lipid-based) were statistically higher for the metabolites pp'DDT (0.464 vs. 0.269) and ss-HCH (0.263 vs. 0.192) in the cryptorchidism group compared to the control group (p<0.01). It could be concluded that the levels of the metabolites pp'DDT and ss-HCH are higher among mothers of newborns with cryptorchidism. It is possible that substances with anti-androgenic effects could produce endocrine disruption, such as cryptorchidism, during fe...Continue Reading

References

Jul 1, 1993·Environmental Health Perspectives·A GiwercmanN E Skakkebaek
Dec 28, 2000·Salud pública de México·S M WaliszewskiJ Siliceo
Feb 3, 2005·Environmental Health Perspectives·Rajiv BhatiaBrenda Eskenazi
Dec 24, 2005·International Journal of Andrology·Lennart HardellMichael Carlberg
Feb 10, 2006·International Journal of Andrology·Thea M EdwardsLouis J Guillette
Jul 5, 2006·Environmental Health Perspectives·Louis J Guillette
Jul 13, 2006·Environmental Health Perspectives·Ida N DamgaardUNKNOWN Nordic Cryptorchidism Study Group
May 27, 2008·Human Reproduction·Françoise Brucker-DavisUNKNOWN Cryptorchidism Study Group from Nice Area

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Citations

Jan 29, 2013·Environmental and Molecular Mutagenesis·Diana Lorena Alvarado-HernandezLeticia Yáñez-Estrada

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