Prenatal exposure to organophosphate pesticides and risk of autism spectrum disorders and other non-typical development at 3 years in a high-risk cohort

International Journal of Hygiene and Environmental Health
Claire PhilippatIrva Hertz-Picciotto

Abstract

Organophosphates are widely used pesticides that have been shown to affect child neurodevelopment. Previous studies that explored their potential effects on Autism Spectrum Disorder (ASD) relied either on proxies of external exposure or on questionnaires completed by the parents to identify autism-like behaviors but did not provide a clinical diagnosis of ASD. We studied the associations between prenatal biologic markers for exposure to organophosphate pesticides and the risk of having a child with ASD or other developmental concerns (ODC). We analyzed 203 mother-child pairs of the ongoing MARBLES (Markers of Autism Risk in Babies - Learning Early Signs) mother-child cohort, which enrolls mothers who are either pregnant or planning a pregnancy and whose expected child has an elevated risk to develop ASD. Seven metabolites of organophosphate pesticides were assessed in repeated urine samples collected during pregnancy. At 36 months, children were assessed with intruments measuring cognitive function and adaptive behaviors, and with two gold-standard diagnostic instruments for ASD: the Autism Diagnostic Observation Schedule and the Autism Diagnostic Interview-Revised. Children were classified in one of the following groups: ASD (...Continue Reading

Citations

May 2, 2019·Environmental Science and Pollution Research International·Ratana Sapbamrer, Surat Hongsibsong
Jul 15, 2020·Reviews on Environmental Health·Samuel VirolainenSarah Dalibalta
Oct 20, 2018·Pediatric Research·James R RobertsJ Routt Reigart
Dec 7, 2018·Environmental Health : a Global Access Science Source·Hyeong-Moo ShinIrva Hertz-Picciotto
Oct 31, 2020·International Journal of Environmental Research and Public Health·Neeranuch SuwannarinShoji F Nakayama
Nov 19, 2020·Anais Da Academia Brasileira De Ciências·Jaqueline N DA SilvaAna Paula A Favareto
Oct 7, 2020·Environmental Research·Claire Philippat, Antonia M Calafat
May 13, 2021·Journal of Autism and Developmental Disorders·Li WangYing Wang
Jun 3, 2021·International Journal of Environmental Research and Public Health·Judit Biosca-BrullMaria Teresa Colomina
Aug 22, 2021·Environmental Research·Viviana RamírezAna Rivas

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