Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and birth outcomes: A longitudinal cohort with repeated measurements.

Chemosphere
Lin ChenShanghai Birth Cohort

Abstract

Previous studies on perfluoroalkyl and polyfluoroalkyl substances (PFAS) showed inconsistent results when biological samples were collected in different time of pregnancy. To describe the change of PFAS concentration during pregnancy and to identify a sensitive window for adverse effects of PFAS on the fetus. A total of 255 pregnant women were selected from the Shanghai Birth Cohort (SBC). We quantified 10 PFAS with high-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS) in maternal plasma at three trimesters and cord blood at delivery. Multiple linear regression analyses were used to analyze the association between PFAS and birth outcomes, including birth weight, birth length, and head circumference. The concentrations of most PFAS declined substantially during pregnancy. PFOS, PFNA, PFDA, PFUA and PFDoA were negatively related to birth length only in the first trimester. The coefficients and 95% confidence intervals (CI) of birth length change with a log-unit increase in PFOS, PFNA, PFDA, PFUS and PFDoA concentrations were -0.27 cm (-0.51, -0.02), -0.34 cm (-0.65, -0.03), -0.27 cm (-0.53, -0.01), -0.29 cm (-0.58, -0.01), and -0.54 cm (-1.00, -0.08), respectively. The effects were only observed for female ...Continue Reading

References

Jul 9, 2004·Toxicology and Applied Pharmacology·Christopher LauJohn M Rogers
Jan 18, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christopher LauMark J Strynar
Aug 4, 2010·Analytical and Bioanalytical Chemistry·Lina KantianiDamià Barceló
Aug 21, 2010·Environmental Science & Technology·Hermann FrommeWolfgang Völkel
Jul 28, 2011·Integrated Environmental Assessment and Management·Robert C BuckStefan P J van Leeuwen
Nov 16, 2012·Journal of Toxicology and Environmental Health. Part a·Anne E LoccisanoHarvey J Clewell
Nov 6, 2014·Critical Reviews in Toxicology·Cathrine Carlsen BachTine Brink Henriksen
Dec 24, 2014·Environmental Health : a Global Access Science Source·Kristian T JørgensenJens Peter Bonde
Jun 10, 2015·Environmental Health Perspectives·Naila KhalilKurunthachalam Kannan
Jan 9, 2017·International Journal of Hygiene and Environmental Health·Christian Bjerregaard-OlesenEva C Bonefeld-Jørgensen
Jun 29, 2017·Environmental Health Perspectives·Wei ZhouUNKNOWN Shanghai Birth Cohort Study
Sep 17, 2017·Environment International·Cyntia B Manzano-SalgadoMartine Vrijheid
Aug 29, 2018·International Journal of Environmental Research and Public Health·Qi MengZeyan Liew
Dec 14, 2018·Surgical and Radiologic Anatomy : SRA·Mariusz BaumgartKatarzyna Pawlak-Osińska
Jan 11, 2019·Environmental Health : a Global Access Science Source·Rong HuangJun Zhang
Jan 11, 2019·International Journal of Epidemiology·Jun ZhangUNKNOWN Shanghai Birth Cohort
Mar 23, 2019·KI Reports·Kate WilesLucy C Chappell
Apr 13, 2019·International Journal of Hygiene and Environmental Health·Kristin J MarksTerryl J Hartman
Jun 4, 2019·Environmental Research·Joaquim RoviraMarta Schuhmacher
Jun 28, 2019·Environment International·Olga CostaMaria-Jose Lopez-Espinosa

❮ Previous
Next ❯

Citations

Mar 29, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Huitao LiRen-Shan Ge

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.