Prenatal exposure to persistent organic pollutants and cognition and motor performance in adolescence

Environment International
Sietske A BerghuisArend F Bos

Abstract

Prenatal exposure to persistent organic pollutants (POPs), such as polychlorinated biphenyls (PCBs), was found to be associated with poorer neurological development in children. Knowledge about the effects on outcomes until adolescence is limited. To determine whether prenatal exposure to POPs, particularly hydroxylated PCBs (OH-PCBs), is associated with cognitive and motor development in 13- to 15-year-old children. This prospective observational cohort study is part of the Development at Adolescence and Chemical Exposure (DACE)-study, a follow-up of two Dutch birth cohorts. Maternal pregnancy serum levels of PCB-153 and three OH-PCBs were measured, in part of the cohort also nine other PCBs and three OH-PCBs, and in another part five polybrominated diphenyl ethers (PBDEs), dichloroethene (DDE), pentachlorophenol (PCP) and hexabroomcyclododecane (HBCDD). Of the 188 invited adolescents, 101 (53.7%) participated, 55 were boys. Cognition (intelligence, attention, verbal memory) and motor performance (fine motor, ball skills, balance) were assessed. Scores were classified into 'normal' (IQ > 85; scores > P15) and '(sub)clinical' (IQ ≤ 85; scores ≤ P15). We used linear and logistic regression analyses, and adjusted for maternal edu...Continue Reading

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Citations

Sep 23, 2020·Toxics·Harmanpreet Kaur PanesarPamela J Lein
Dec 21, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Dianjianyi SunLu Qi
Dec 15, 2020·Toxicology and Applied Pharmacology·Jong-Hui KimSu-Hyun Jo
Nov 11, 2019·International Journal of Hygiene and Environmental Health·Eva M TannerEdward F Fitzgerald
Jan 8, 2021·Current Epidemiology Reports·Ann M VuongAimin Chen
Mar 19, 2021·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Christiane Vleminckx

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