Prenatal exposure to pesticides and risk for holoprosencephaly: a case-control study

Environmental Health : a Global Access Science Source
Yonit A AddissieM Muenke

Abstract

Pesticide exposure during susceptible windows and at certain doses are linked to numerous birth defects. Early experimental evidence suggests an association between active ingredients in pesticides and holoprosencephaly (HPE), the most common malformation of the forebrain in humans (1 in 250 embryos). No human studies to date have examined the association. This study investigated pesticides during multiple windows of exposure and fetal risk for HPE. It is hypothesized that pre-conception and early pregnancy, the time of brain development in utero, are the most critical windows of exposure. A questionnaire was developed for this retrospective case-control study to estimate household, occupational, and environmental pesticide exposures. Four windows of exposure were considered: preconception, early, mid and late pregnancy. Cases were identified through the National Human Genome Research Institute's ongoing clinical studies of HPE. Similarly, controls were identified as children with Williams-Beuren syndrome, a genetic syndrome also characterized by congenital malformations, but etiologically unrelated to HPE. We assessed for differences in odds of exposures to pesticides between cases and controls. Findings from 91 cases and 56 c...Continue Reading

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Citations

Aug 9, 2020·Alcoholism, Clinical and Experimental Research·Joshua L EversonJohann K Eberhart
Oct 29, 2020·Birth Defects Research·Yonit A AddissiePaul Kruszka
Apr 11, 2021·European Journal of Nutrition·Narimane DjekkounHafida Khorsi-Cauet

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Clinical Trials Mentioned

NCT00088426
NCT02706639

Software Mentioned

R
ELEAT
Early Life Exposures Assessment Tool ( ELEAT )

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