Prenatal exposure to phthalates is associated with decreased anogenital distance and penile size in male newborns

Journal of Developmental Origins of Health and Disease
L P Bustamante-MontesV H Borja-Aburto

Abstract

Reproductive effects from phthalate exposure have been documented mostly in animal studies. This study explored the association between prenatal exposure to phthalate metabolites, anogenital distance and penile measurements in male newborns in Toluca, State of Mexico. A total of 174 pregnant women provided urine samples for phthalate analysis during their last prenatal visit, and the 73 who gave birth to male infants were included in the study. The 73 male newborns were weighed and measured using standardized methods after delivery. After adjusting for creatinine and supine length at birth, significant inverse associations were observed between an index of prenatal exposure to total phthalate exposure and the distance from the anus to anterior base of the penis (β = -0.191 mm per 1 μg/l, P = 0.037), penile width (β = -0.0414, P = 0.050) and stretched length (β = -0.2137, P = 0.034); prenatal exposure to mono-2-ethylhexyl phthalate exposure was associated with a reduction in the stretched length of the penis (β = -0.2604, P = 0.050). Human exposure to phthalates is a public health concern, and the system most vulnerable to its potential effects seems to be the immature male reproductive tract.

References

Jul 1, 1978·The Journal of Pediatrics·H CapurroR Caldeyro-Barcia
Apr 1, 1987·Acta Paediatrica Japonica; Overseas Edition·K Fujieda, N Matsuura
Feb 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T J Gray, J A Beamand
Jun 1, 1996·Pediatrics in Review·H AnhaltR L Hintz
Dec 2, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·L G ParksL E Gray
May 11, 2002·Environmental Health Perspectives·Jane A HoppinDonna D Baird
May 30, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christopher J BowmanPaul M D Foster
Sep 15, 2004·Environmental Health : a Global Access Science Source·Eduardo Salazar-MartinezMauricio Hernandez-Avila
Dec 8, 2004·Environmental Health Perspectives·Russ HauserAntonia M Calafat
Jan 25, 2005·Biology of the Neonate·T F FokUNKNOWN Hong Kong Neonatal Measurements Working Group
Aug 5, 2005·Environmental Health Perspectives·Shanna H SwanUNKNOWN Study for Future Families Research Team
Feb 10, 2006·International Journal of Andrology·Ted Schettler
Jul 13, 2006·Risk Analysis : an Official Publication of the Society for Risk Analysis·Matthias WormuthKonrad Hungerbühler
Jan 30, 2007·Reproductive Toxicology·Ren-Shan GeMatthew P Hardy
Apr 19, 2007·Paediatric and Perinatal Epidemiology·S Patricia Romano-RiquerMatthew P Longnecker
Apr 17, 2008·Environmental Health Perspectives·Jennifer J AdibiRuss Hauser
Jul 22, 2008·Environment International·Po-Chin HuangChing-Chang Lee
Mar 8, 2011·Environmental Health Perspectives·Jaime MendiolaShanna H Swan
Mar 25, 2011·Environment International·Michelle Romero-FrancoLizbeth López-Carrillo
Jun 24, 2011·International Journal of Andrology·Y SuzukiH Shiraishi
Jun 24, 2011·Environmental Research·Katherine SvenssonLizbeth López-Carrillo

❮ Previous
Next ❯

Citations

Jan 30, 2014·Environmental Science and Pollution Research International·Chunhua LiuXia Huo
Oct 31, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·E B Mallow, M A Fox
Feb 16, 2016·The Science of the Total Environment·Tye E ArbuckleGeorge Tawagi
Dec 23, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sean HarrisElaine M Faustman
Jun 30, 2015·Environment International·Cécile MarieMarie-Pierre Sauvant-Rochat
Sep 28, 2015·The Science of the Total Environment·Thuy T BuiCynthia A de Wit
Mar 7, 2015·Environmental Research·Jonatan AxelssonAleksander Giwercman
Mar 13, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Nathalie PhamMelanie Marty
Jul 5, 2016·Journal of Developmental Origins of Health and Disease·J D Bowman, M Choudhury
Aug 23, 2016·Annals of Epidemiology·Gerard M H SwaenMaurice P Zeegers
Nov 21, 2017·Pediatric Research·Lærke PriskornTina K Jensen
Aug 24, 2018·Neurourology and Urodynamics·María L Sánchez-FerrerAlberto M Torres-Cantero
Oct 30, 2014·Environmental Health Perspectives·Carl-Gustaf BornehagShanna H Swan
Feb 26, 2016·Environmental Health Perspectives·Tina Harmer LassenTina Kold Jensen
Sep 11, 2018·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·David C DormanKatrina M Waters
Dec 17, 2015·Environmental Health Perspectives·Tina Kold JensenAnna-Maria Andersson
Aug 5, 2015·Endocrinology·Emily S Barrett, Shanna H Swan
Jan 15, 2015·Journal of Developmental Origins of Health and Disease·E S BarrettS H Swan
Apr 28, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Randall JenkinsDavid Rozansky
Jun 8, 2019·Risk Analysis : an Official Publication of the Society for Risk Analysis·Carl-Gustaf BornehagChris Gennings
Jan 8, 2020·International Journal of Environmental Research and Public Health·Julia R VarshavskyThu Quach
Sep 29, 2020·Frontiers in Public Health·Yiyu QianYing Hua
Feb 24, 2015·Human Reproduction·S H SwanUNKNOWN TIDES Study Team
Dec 29, 2020·Archives of Environmental & Occupational Health·Ariana Rodríguez Arreola, A Aaron Peregrina-Lucano
May 1, 2021·Toxics·Randall JenkinsDavid Rozansky
May 1, 2021·International Journal of Molecular Sciences·Laura LucaccioniLorenzo Iughetti
May 28, 2021·Toxicology Reports·Lilia Patricia Bustamante-MontesGermán Antonio Acosta-Gordillo
Jul 24, 2021·Toxicology Reports·Lilia Patricia Bustamante-MontesRafael González-Álvarez
Jul 30, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Álvaro López-SotoJuan Pedro Martínez-Cendán
Aug 5, 2021·Current Research in Toxicology·Deidre M Mattiske, Andrew J Pask
Oct 8, 2021·Molecular Reproduction and Development·Inês MesquitaElisa Cairrao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.