Prenatal exposure to selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors and risk for persistent pulmonary hypertension of the newborn: a systematic review, meta-analysis, and network meta-analysis

American Journal of Obstetrics and Gynecology
Reem MasarwaIlan Matok

Abstract

There is a marked increase in the use of selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors in the last decade. Many newborns are likely to be exposed during pregnancy and labor. We aimed to evaluate the association between exposure to selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors during pregnancy and the risk for persistent pulmonary hypertension of the newborn. We sought to compare the risk for persistent pulmonary hypertension of the newborn between specific selective serotonin reuptake inhibitor agents. MEDLINE, Embase, and Cochrane were searched up to July 2017. No language restrictions were applied. Search key words included: "SSRI," "SNRI," "pregnancy," "risk," "new-born," and "pulmonary hypertension." Retrospective cohort studies and case-control studies reporting the risk for persistent pulmonary hypertension of the newborn in the offspring of women exposed to selective serotonin reuptake inhibitors or serotonin norepinephrine reuptake inhibitors during pregnancy, were extracted. Two independent researchers identified relevant data. Random effects meta-analysis was used to pool results. Odds ratios were calculated with subsequent 95% confi...Continue Reading

Citations

Sep 16, 2020·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Louise M Howard, Hind Khalifeh
Oct 3, 2019·JAMA Psychiatry·Elena DragiotiEvangelos Evangelou
Feb 18, 2020·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Marit L Bovbjerg, Veronica Irvin
Dec 29, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Georgios SchoretsanitisOlav Spigset
Jan 7, 2022·Obstetrics and Gynecology·Alison N GouldingBradley N Gaynes

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