Prenatal Exposure to Sodium Arsenite Alters Placental Glucose 1, 3, and 4 Transporters in Balb/c Mice

BioMed Research International
Daniela Sarahí Gutiérrez-TorresBlanca Sánchez-Ramírez

Abstract

Inorganic arsenic (iAs) exposure induces a decrease in glucose type 4 transporter (GLUT4) expression on the adipocyte membrane, which may be related to premature births and low birth weight infants in women exposed to iAs at reproductive age. The aim of this study was to analyze the effect of sodium arsenite (NaAsO2) exposure on GLUT1, GLUT3, and GLUT4 protein expression and on placental morphology. Female Balb/c mice (n = 15) were exposed to 0, 12, and 20 ppm of NaAsO2 in drinking water from 8th to 18th day of gestation. Morphological changes and GLUT1, GLUT3, and GLUT4 expression were evaluated in placentas by immunohistochemical and image analysis and correlated with iAs and arsenical species concentration, which were quantified by atomic absorption spectroscopy. NaAsO2 exposure induced a significant decrease in fetal and placental weight (P < 0.01) and increases in infarctions and vascular congestion. Whereas GLUT1 expression was unchanged in placentas from exposed group, GLUT3 expression was found increased. In contrast, GLUT4 expression was significantly lower (P < 0.05) in placentas from females exposed to 12 ppm. The decrease in placental GLUT4 expression might affect the provision of adequate fetal nutrition and explai...Continue Reading

References

Jul 1, 1992·Environmental Health Perspectives·A H SmithM T Smith
Apr 1, 1991·Clinical and Experimental Pharmacology & Physiology·M J LeroyF Ferré
Jul 1, 1995·The Journal of Clinical Investigation·P BoileauS Hauguel-de Mouzon
Sep 16, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T HahnG Desoye
Sep 22, 1998·Toxicological Sciences : an Official Journal of the Society of Toxicology·G ConchaM Vahter
Nov 14, 1998·The Journal of Clinical Endocrinology and Metabolism·A Y XingS Hauguel-de Mouzon
Nov 17, 1998·Toxicology Letters·A Hernández-ZavalaM E Cebrián
Dec 5, 1998·International Journal of Epidemiology·D N Guha MazumderA H Smith
Feb 4, 1999·Hypertension·M RahmanO Axelson
Feb 29, 2000·Placenta·N P Illsley
Jun 6, 2000·Advanced Drug Delivery Reviews·G T KnippM J Soares
Jul 11, 2001·Environmental Health Perspectives·S A AhmadH K Talukder
Aug 4, 2001·Toxicology and Applied Pharmacology·L M Del RazoD J Thomas
Apr 13, 2002·Toxicologic Pathology·Eveline P C T de RijkGert Flik
Sep 10, 2003·Toxicology Letters·V M RodríguezM Giordano
Sep 27, 2003·European Journal of Biochemistry·Merlijn BazuineJ Antonie Maassen
Jan 13, 2004·Human Reproduction Update·A MalassinéD Evain-Brion
Feb 18, 2004·The Journal of Biological Chemistry·Zijuan LiuBarry P Rosen
Jul 28, 2004·Toxicology and Applied Pharmacology·Felecia S WaltonMiroslav Styblo
Sep 24, 2004·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Margarita Levario-CarrilloEstela Bevilacqua
Jan 18, 2006·Toxicology and Applied Pharmacology·Andrea Díaz-VillaseñorMarcia Hiriart
Aug 31, 2006·International Journal of Toxicology·Amy WangJohn L Robertson
Oct 27, 2006·Biochemical and Biophysical Research Communications·Zijuan LiuBarry P Rosen
Jun 16, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Wenjie HeJ Douglas Coffin
Jul 25, 2008·Human & Experimental Toxicology·B González-GarcíaB Sánchez-Ramírez
May 19, 2009·Toxicology and Applied Pharmacology·Denise S HillRichard H Finnell
Jul 7, 2009·Annual Review of Nutrition·Marie Vahter
Nov 12, 2010·Metallomics : Integrated Biometal Science·Xuan JiangZijuan Liu
Nov 10, 2011·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·M E Dávila-EsquedaS Martin-Pérez
Jan 14, 2012·Human & Experimental Toxicology·E González-PueblaB Sánchez-Ramírez
Mar 28, 2012·Biological Trace Element Research·Huai GuanKazuhito Yokoyama
Apr 17, 2012·Environmental Health Perspectives·Kuntal K SahaMarie Vahter
Jan 11, 2013·Journal of Pregnancy·Susanne Lager, Theresa L Powell
Jul 19, 2013·Toxicology and Applied Pharmacology·Shohreh F FarzanYu Chen

❮ Previous
Next ❯

Software Mentioned

STATA
IMAGE proplus

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.