Prenatal exposure to the contaminant perfluorooctane sulfonate elevates lipid peroxidation during mouse fetal development but not in the pregnant dam

Free Radical Research
Y Y LeeJ C-Y Lee

Abstract

Perfluorooctane sulfonate (PFOS), a member of the perfluorinated chemical family, has been convincingly demonstrated to affect lipid metabolism in animals and humans and readily crosses the placenta to exert its effects on the developing fetuses. While its exact mechanism is still not clear, PFOS exposure has long been suggested to exert its toxicity via oxidative stress and/or altered gene expression. Levels of PFOS and malondialdehyde in various organs and cell cultures have been widely determined as general indicators of non-specific lipid peroxidation after PFOS exposure. In this study, the oxidation of precise polyunsaturated fatty acids and their metabolites, derived from enzymatic and non-enzymatic pathways was determined following PFOS exposure in both adult and maternal/fetal mice. CD-1 mice were exposed to 3 mg/kg body weight/day of PFOS in corn oil by oral gavage until late gestation (GD17). We demonstrated that lipid peroxidation was particularly and exclusively affected in fetuses exposed to PFOS, but this was not the case in the maternal mice, where limited effects were observed in the enzymatic oxidation pathway. In this study, we demonstrated that PFOS-induced lipid peroxidation might have a greater impact in fr...Continue Reading

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J D MorrowL J Roberts
May 1, 1986·Archives of Biochemistry and Biophysics·B Halliwell, J M Gutteridge
May 12, 2001·Environmental Science & Technology·J P Giesy, K Kannan
May 10, 2002·Environmental Science & Technology·John P Giesy, Kurunthachalam Kannan
May 30, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christopher LauLisa A Stevenson
May 30, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Julie R ThibodeauxChristopher Lau
Jan 31, 2004·Environmental Science & Technology·Jonathan W MartinScott A Mabury
Aug 27, 2004·Critical Reviews in Toxicology·Gerald L KennedyDavid G Farrar
Jul 18, 2006·The American Journal of Clinical Nutrition·Linda M ArterburnHarry Oken
Mar 27, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Matthew T MartinDavid J Dix
Nov 27, 2007·Free Radical Biology & Medicine·Chutima MatayatsukBarry Halliwell
Jan 30, 2008·Free Radical Biology & Medicine·Chung-Yung J LeeBarry Halliwell
Jul 25, 2008·Environmental Research·Rocio MonroyWarren G Foster
May 2, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·James A Bjork, Kendall B Wallace
Mar 5, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xiongjie Shi, Bingsheng Zhou
Jun 1, 2010·Neurotoxicity Research·Natalia OnishchenkoSandra Ceccatelli
Aug 3, 2011·Environmental Science & Technology·Sunmi KimJohn P Giesy
Sep 6, 2011·Reproductive Toxicology·Shu-Ching ChangJohn L Butenhoff
Apr 6, 2012·Frontiers in Pharmacology·Norman R SaundersKatarzyna M Dziegielewska
Apr 10, 2012·Biochimica Et Biophysica Acta·H T WanChris K C Wong
Dec 12, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ming Long Sirius ChungChung-Yung Jetty Lee
Feb 16, 2013·Journal of Hazardous Materials·H T WanChris K C Wong
Feb 27, 2014·Chemistry and Physics of Lipids·Kin Sum LeungChung-Yung Jetty Lee

❮ Previous
Next ❯

Citations

Jan 26, 2016·International Journal of Environmental Research and Public Health·Jillian Ashley-MartinWilliam Fraser
Jun 28, 2017·Environmental Science & Technology·Keng Po LaiChris Kong-Chu Wong
May 2, 2019·Environmental Science and Pollution Research International·Xiaoliu LiangBin Yang
Sep 20, 2017·Progress in Lipid Research·Jean-Marie GalanoJetty Chung-Yung Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.