Prenatal exposure to the Great Chinese Famine and mid-age hypertension

PloS One
Lei WuZhice Xu

Abstract

One of the most terrible famines last century was Great Chinese Famine (GCF) in 1959~1961 when millions of people died from starving. Under-nutrition during famine between the Western and Eastern (Dutch Hungry vs. GCF) was similar, while cardiovascular consequences might not be the same. Addressing such questions may gain new insight into prevention of cardiovascular diseases. A retrospective cohort of 18,593 participants aged 43-49 years of old, was from Suzhou, China. Logistic regression model was used to calculate the relative risk (RR) of hypertension and corresponding 95% confidence interval (CI). The multivariate RRs were adjusted for age, plasma glucose, triglyceride, and cholesterol. The multivariate RRs of systolic and diastolic pressure were not significantly elevated in the rural subgroups, but was higher in the urban population born in the famine (systolic pressure adjust RR 1.382, 95% CI 1.235-1.545, diastolic pressure adjust RR 1.569, 95% CI 1.415-1.740). The risks of hypertension were significantly higher among the urban subjects than that in the rural subgroups (systolic hypertension adjust RR 2.915, 95% CI 2.616-3.249, diastolic hypertension adjust RR 4.568, 95% CI 4.079-5.116). Percentile of optimal diastolic ...Continue Reading

References

Jul 13, 1985·British Medical Journal·A S Truswell
May 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·A S BrownJ M Gorman
Nov 10, 1995·International Journal of Cardiology·X WuD Fan
Dec 22, 1999·BMJ : British Medical Journal·V Smil
Feb 15, 2000·The American Journal of Psychiatry·A S BrownE S Susser
Nov 13, 2001·Clinical and Experimental Pharmacology & Physiology·L J EdwardsI C McMillen
Jun 14, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Amar Akhtar SethiAnne Tybjaerg-Hansen
Nov 25, 2003·Paediatric and Perinatal Epidemiology·Tessa J RoseboomOtto P Bleker
Jul 23, 2004·Nature·Patrick BatesonSonia E Sultan
Jan 11, 2005·Journal of the American College of Nutrition·D J P Barker
Feb 2, 2006·Diabetes, Obesity & Metabolism·V BaskarB M Singh
Feb 10, 2006·JAMA : the Journal of the American Medical Association·Barbara V HowardJane Morley Kotchen
Jul 29, 2006·Diabetes Care·Susanne R de RooijTessa J Roseboom
Aug 1, 2006·Early Human Development·Tessa RoseboomRebecca Painter
Aug 18, 2006·Journal of Hypertension·Rebecca C PainterTessa J Roseboom
Jan 15, 2008·Addiction·Ernst J FranzekBen J M Van De Wetering
May 13, 2009·Molecular and Cellular Endocrinology·Emmanuel SommPetra S Hüppi
Jul 1, 2009·Nature Reviews. Cardiology·Cristiana VitaleGiuseppe M C Rosano
Jul 23, 2009·JAMA : the Journal of the American Medical Association·John P FormanGary C Curhan
Aug 31, 2014·Revista Española De Cardiología·Silvia Berciano, José M Ordovás

❮ Previous
Next ❯

Citations

Jun 8, 2018·Frontiers in Physiology·Pilar Rodríguez-RodríguezSilvia M Arribas
Oct 22, 2020·Cellular and Molecular Life Sciences : CMLS·Caitlyn E BowmanMichael J Wolfgang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.