Prenatal exposure to thyroid hormone is necessary for normal postnatal development of murine heart and lungs

Developmental Biology
Minke van TuylWouter H Lamers

Abstract

Maternal hypothyroxinemia during early pregnancy poses an increased risk for poor neuropsychological development of the fetus. We tested the hypothesis that maternal hypothyroidism before the onset of fetal thyroid function also affects postnatal development of heart and lungs. This question was addressed in transgenic mice that express herpes simplex virus thymidine kinase in their thyroidal follicle cells. Treatment with ganciclovir rendered these mice severely hypothyroid because viral thymidine kinase converts ganciclovir into a cytotoxic nucleoside analog. Since ganciclovir crosses the placenta, it also destroyed the thyroid of transgenic embryos while leaving the thyroids of nontransgenic littermates unaffected. Hypothyroidism of both mother and fetus did not affect prenatal heart and lung development. However, the postnatal switch from beta- to alpha-myosin heavy chain (beta- and alpha-MHC, respectively) gene expression and the increase of SERCA-2a mRNA expression did not occur in the ventricular myocardium of either the transgenic (thyroid destroyed) or nontransgenic (intact thyroid) offspring of hypothyroid mothers. Similarly, postnatal animals of the latter two groups retained elevated surfactant protein (SP) A, B, an...Continue Reading

References

Jul 29, 1992·Biochimica Et Biophysica Acta·I Connelly, F Possmayer
Dec 1, 1991·Endocrinology·H WallaceR al-Shawi
May 1, 1991·American Journal of Respiratory Cell and Molecular Biology·J FlorosS M Peterec
Feb 21, 1991·The New England Journal of Medicine·J G Thorpe-BeestonA M McGregor
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T R KorfhagenJ A Whitsett
Jun 1, 1987·Circulation Research·V MahdaviB Nadal-Ginard
Oct 1, 1985·The Journal of Clinical Investigation·D MassaroP Whitney
Mar 19, 1981·The New England Journal of Medicine·D A Fisher, A H Klein
Jul 1, 1981·The Journal of Clinical Endocrinology and Metabolism·L W Gonzales, P L Ballard
Dec 1, 1984·European Heart Journal·W A ClarkR Zak
Apr 3, 1981·Science·W J BeamerJ L Southard
May 1, 1995·The Journal of Endocrinology·H WallaceJ O Bishop
Apr 1, 1993·The Histochemical Journal·A F MoormanW H Lamers
Dec 29, 1994·The New England Journal of Medicine·X Y CaoG R DeLong
Oct 20, 1994·The New England Journal of Medicine·G N BurrowP R Larsen
Aug 1, 1995·Journal of Molecular and Cellular Cardiology·R VetterH Drexler
Jan 1, 1995·Reproduction, Fertility, and Development·D H Polk
Oct 1, 1996·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L ZhouJ A Whitsett
Mar 1, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A JonkerA F Moorman
Jan 1, 1997·Molecular and Cellular Neurosciences·S C AhlgrenM C Raff
Jul 20, 1999·European Journal of Biochemistry·W H LamersA F Moorman
Aug 19, 1999·The New England Journal of Medicine·J E HaddowR Z Klein
Jan 5, 2000·The New England Journal of Medicine·C Herzmann, J K Torrens

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Citations

Aug 6, 2009·Environmental Health Perspectives·Mark D MillerR Thomas Zoeller
Apr 20, 2006·BMC Pulmonary Medicine·Simone A J ter HorstGerry T M Wagenaar
May 7, 2010·Environmental Health Perspectives·Mark D Miller, Melanie A Marty
Oct 7, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Natasha N ChattergoonKent L Thornburg
Nov 4, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jiatong HouShi Chen
Sep 1, 2015·Molecular and Cellular Endocrinology·Milica VujovicJens Mittag
Jan 15, 2015·Stem Cells and Development·Christiaan C VeermanMilena Bellin
Aug 8, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·K de Picoli Souza, M T Nunes
May 4, 2018·Journal of Molecular Endocrinology·Emma J AgnewKaren E Chapman
May 24, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Esmond J Sanders, Steve Harvey
Feb 12, 2019·ERJ Open Research·Jacob Shujui HsuMaria-Mercè Garcia-Barcelo
Mar 20, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Madan M GodboleSwasti Tiwari
Sep 9, 2019·Biology of Reproduction·Enoch Appiah Adu-GyamfiYu-Bin Ding
Feb 9, 2007·Muscle & Nerve·Muthu Periasamy, Anuradha Kalyanasundaram
Aug 28, 2019·Journal of Molecular Evolution·Iordanis MourouzisChristodoulos Xinaris
Feb 7, 2020·Physiology·Rochelle BuffensteinHolly M Brown-Borg
Jun 28, 2020·Scientific Reports·Julie K WatsonDonna K Finch
Jun 21, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Rolf H SlaatsRobert Passier
May 2, 2021·Seminars in Cell & Developmental Biology·Emmanouil Tampakakis, Ahmed I Mahmoud
Aug 24, 2020·Developmental Biology·Janet Palacios-MartinezAlfredo Cruz-Ramirez

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