Prenatal factors contribute to the emergence of kwashiorkor or marasmus in severe undernutrition: evidence for the predictive adaptation model.

PloS One
T ForresterPeter D Gluckman

Abstract

Severe acute malnutrition in childhood manifests as oedematous (kwashiorkor, marasmic kwashiorkor) and non-oedematous (marasmus) syndromes with very different prognoses. Kwashiorkor differs from marasmus in the patterns of protein, amino acid and lipid metabolism when patients are acutely ill as well as after rehabilitation to ideal weight for height. Metabolic patterns among marasmic patients define them as metabolically thrifty, while kwashiorkor patients function as metabolically profligate. Such differences might underlie syndromic presentation and prognosis. However, no fundamental explanation exists for these differences in metabolism, nor clinical pictures, given similar exposures to undernutrition. We hypothesized that different developmental trajectories underlie these clinical-metabolic phenotypes: if so this would be strong evidence in support of predictive adaptation model of developmental plasticity. We reviewed the records of all children admitted with severe acute malnutrition to the Tropical Metabolism Research Unit Ward of the University Hospital of the West Indies, Kingston, Jamaica during 1962-1992. We used Wellcome criteria to establish the diagnoses of kwashiorkor (n = 391), marasmus (n = 383), and marasmic...Continue Reading

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References

Jan 1, 1997·American Journal of Public Health·P GaskinS M Grantham-McGregor
Mar 11, 2000·American Journal of Physiology. Endocrinology and Metabolism·M ReidF Jahoor
Aug 29, 2002·The American Journal of Clinical Nutrition·Asha BadalooFarook Jahoor
Nov 27, 2002·The American Journal of Clinical Nutrition·Marvin ReidFarook Jahoor
Jun 10, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M H VickersP D Gluckman
Jul 23, 2004·Nature·Patrick BatesonSonia E Sultan
Sep 18, 2004·Science·Peter D Gluckman, Mark A Hanson
Jun 10, 2006·The American Journal of Clinical Nutrition·Asha V BadalooFarook Jahoor
Aug 3, 2006·Maternal & Child Nutrition·Jesse SullivanMark J Manary
Jul 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Peter D GluckmanMark A Hanson
Jan 22, 2008·Lancet·Cesar G VictoraUNKNOWN Maternal and Child Undernutrition Study Group
Jan 22, 2008·Lancet·Robert E BlackUNKNOWN Maternal and Child Undernutrition Study Group
May 31, 2008·Annals of Tropical Paediatrics·Farook JahoorTerrence Forrester
Oct 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Bastiaan T HeijmansL H Lumey
Oct 26, 2010·Indian Pediatrics·Michael H Golden
Aug 30, 2011·Lancet·Boyd A SwinburnSteven L Gortmaker

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Citations

Oct 14, 2014·Journal of Developmental Origins of Health and Disease·E C MacaulayUNKNOWN Gravida International College Summit Team
Jun 3, 2014·The Journal of Physiology·Patrick BatesonMark Hanson
Nov 11, 2015·Proceedings of the National Academy of Sciences of the United States of America·Ling LiEve Syrkin Wurtele
Aug 7, 2013·Proceedings of the National Academy of Sciences of the United States of America·Adam D HaywardVirpi Lummaa
Jan 29, 2016·Evolution, Medicine, and Public Health·Claudia P CampbellTerrence E Forrester
Jul 2, 2014·Hypertension·Ingrid A TennantTerrence E Forrester
Feb 13, 2014·The Journal of Clinical Endocrinology and Metabolism·Patrice M Francis-EmmanuelMichael S Boyne
Apr 21, 2020·Medical Anthropology Quarterly·Margaret Lock
Aug 9, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nicola M GrissomTeresa M Reyes
Jul 30, 2014·Food and Nutrition Bulletin·Gerardo WeisstaubRicardo Uauy
Jun 28, 2017·Nutrition Journal·Juliana Rombaldi BernardiMarco Antônio Barbieri
Apr 11, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Thomas C Williams, Amanda J Drake
Apr 11, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jonathan C K Wells
Aug 6, 2020·Journal of Family Medicine and Primary Care·Dhilip KumarTej Bali Singh
Jan 5, 2020·Eating and Weight Disorders : EWD·Pegah Nasiri-BabadiHamed Pouraram
Sep 10, 2019·Evolutionary Anthropology·Amy LuNoah Snyder-Mackler
Apr 11, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Peter D GluckmanFelicia M Low
May 21, 2019·BioSocieties·Clémence PinelChristopher McKevitt
Jan 2, 2019·Proceedings of the National Academy of Sciences of the United States of America·Mary Jane West-Eberhard
Nov 18, 2020·JCI Insight·Debbie S ThompsonRobert H J Bandsma
Jan 14, 2021·Journal of Developmental Origins of Health and Disease·Hamish G SpencerGraeme C Wake
May 23, 2021·Reviews on Environmental Health·Rolf Nieder, Dinesh K Benbi

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