Prenatal factors influencing long-term outcome

Hormone Research
E DennisonD Barker

Abstract

Animal studies have shown that undernutrition before birth programmes persisting changes in a range of metabolic, physiological and structural parameters. Studies in humans have shown that men and women who had birth weights at the lower end of the normal range, who were thin or short at birth, or who were small in relation to placental size, have increased rates of coronary heart disease. This article suggests how fetal undernutrition at different stages of gestation may be linked to these patterns of early growth. Adaptations by the fetus to undernutrition are associated with changes in the concentrations of fetal placental hormones. Persisting changes in the level of hormone secretion and tissue sensitivity may link fetal undernutrition with adult disease.

Citations

Oct 7, 2008·Advances in Therapy·Heike JungStenvert L S Drop
Apr 6, 1999·The American Journal of Medicine·P von der ReckeC Hassager
Jun 6, 2007·American Journal of Obstetrics and Gynecology·R B GovindanHari Eswaran
Sep 18, 2016·American Journal of Reproductive Immunology : AJRI·Ann E RoznerThaddeus G Golos
Feb 15, 2001·International Journal of Epidemiology·J E Harding
Jul 31, 2001·European Journal of Clinical Nutrition·X XuJ Karlberg
Aug 4, 2019·International Journal of Environmental Research and Public Health·Gang ChengYan Yan

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