Abstract
Previous studies have suggested that prenatal maternal folate deficiency is associated with reduced prenatal brain growth and psychological problems in offspring. However, little is known about the longer-term impact. The aims of this study were to investigate whether prenatal maternal folate insufficiency, high total homocysteine levels and low vitamin B12 levels are associated with altered brain morphology, cognitive and/or psychological problems in school-aged children. This study was embedded in Generation R, a prospective population-based cohort study. The study sample consisted of 256 Dutch children aged between 6 and 8 years from whom structural brain scans were collected using MRI. The mothers of sixty-two children had insufficient (9·1 µmol/l) predicted poorer performance on the language (B -0·31; 95 % CI -0·56, -0·06; P=0·014) and visuo-spatial domains (B -0·36; 95 % CI -0·60, -0·11; P=0·004). No associations with psychological problems were found. Our findings suggest that folate insufficiency in early pregnancy has a long-lasting, global effect on brain development and is, together with homocysteine levels, associated with poorer cognitive performance.
References
May 29, 2001·Cerebral Cortex·M D De BellisA M Boring
Jan 11, 2005·Birth Defects Research. Part A, Clinical and Molecular Teratology·Suhong XiaoAśok C Antony
Sep 22, 2007·Journal of the American Academy of Child and Adolescent Psychiatry·Nouchka T TickFrank C Verhulst
Nov 14, 2007·Acta Psychiatrica Scandinavica·N T TickF C Verhulst
Jan 31, 2009·Nutritional Neuroscience·Constanza del Río GarciaLizbeth López-Carrillo
Sep 24, 2009·The British Journal of Nutrition·Sabine J RozaHenning Tiemeier
Oct 31, 2009·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Wolff SchlotzKeith M Godfrey
Mar 26, 2010·The Journal of Nutrition·Sargoor R VeenaCaroline H D Fall
Aug 30, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·C BertiI Cetin
Oct 28, 2011·The Proceedings of the Nutrition Society·David Benton
Feb 7, 2012·Scandinavian Journal of Clinical and Laboratory Investigation·Lars H Breimer, Torbjörn K Nilsson
Jun 13, 2012·Paediatric and Perinatal Epidemiology·Eduardo VillamorEmily Oken
Oct 23, 2012·European Journal of Epidemiology·Vincent W V JaddoeAlbert Hofman
Jan 29, 2013·European Journal of Epidemiology·Tonya WhiteFrank C Verhulst
Citations
Apr 30, 2017·Human Molecular Genetics·Doretta CaramaschiCaroline L Relton
Oct 25, 2017·European Journal of Epidemiology·Tonya WhiteHenning Tiemeier
Sep 19, 2017·Molecular Nutrition & Food Research·Zhonghai YanHailong Ou
Mar 2, 2017·The Journal of Biological Chemistry·Stephanie Olivier-Van StichelenJohn A Hanover
Mar 1, 2020·Journal of Neuroscience Research·Hiba Al RubayeNafisa M Jadavji
Aug 25, 2020·Autism Research : Official Journal of the International Society for Autism Research·Masoud AmiriTonya White
Jul 5, 2018·JAMA Psychiatry·Tomáš Paus
Nov 2, 2019·BMC Medicine·Helene McNultyKristina Pentieva
Apr 4, 2020·European Journal of Clinical Nutrition·Xiangyuan HuangWeili Yan
Jun 12, 2020·Nutrients·Marta Cosín-TomásRima Rozen
Jan 11, 2017·European Journal of Epidemiology·Marjolein N KooijmanVincent W V Jaddoe
Jul 14, 2018·Maternal and Child Health Journal·Susan ThomasKrishnamachari Srinivasan
Sep 10, 2020·Nutrients·Hatim AzaryahCristina Campoy
Jul 8, 2020·Molecular Psychiatry·Nadia CattaneAnnamaria Cattaneo
Jul 8, 2020·Biomolecules·Olga YakovlevaGuzel Sitdikova
Jul 28, 2017·European Journal of Nutrition·Szabolcs PéterManfred Eggersdorfer
Nov 18, 2018·Nutrition Reviews·Rafael BarraAlejandro Hernández