Prenatal genesis of layer II doublecortin expressing neurons in neonatal and young adult guinea pig cerebral cortex

Frontiers in Neuroanatomy
Yan YangXiao-Xin Yan

Abstract

Cells expressing doublecortin (DCX+) occur at cortical layer II, predominantly over the paleocortex in mice/rats, but also across the neocortex among larger mammals. Here, we explored the time of origin of these cells in neonatal and 2-month-old guinea pigs following prenatal BrdU pulse-chasing. In the neocortex, BrdU+ cells birth-dated at embryonic day 21 (E21), E28, and E35 laminated over the cortical plate with an inside-out order. In the piriform cortex, cells generated at E21 and E28 occurred with a greater density in layer II than III. Many cells were generated at later time points until birth, occurring in the cortex without a laminar preference. DCX+ cells in the neocortex and piriform cortex partially co-colocalized with BrdU (up to 7.5%) in the newborns after pulse-chasing from E21 to E49 and in the 2 month-old animals after pulse-chasing from E28 to E60/61, with higher rates seen among the E21-E35 groups. Together, layer II DCX+ cells in neonatal and young adult guinea pigs may be produced over a wide prenatal time window, but mainly during the early phases of corticogenesis. Our data also show an earlier establishment of the basic lamination in the piriform relative to neocortical areas in guinea pigs.

References

Feb 21, 1992·Brain Research. Developmental Brain Research·X X YanL J Garey
May 15, 1991·The Journal of Comparative Neurology·S A BayerJ A Simmons
Jan 1, 1990·Experimental Neurology·S A Bayer, J Altman
Jan 1, 1986·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S A Bayer
Dec 22, 1985·The Journal of Comparative Neurology·M B Luskin, C J Shatz
Feb 1, 1995·Anatomy and Embryology·M P IgnacioR T Robertson
Sep 15, 2001·The European Journal of Neuroscience·J NacherB S McEwen
Aug 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·Patrick J BernierAndre Parent
Apr 11, 2006·Neuroreport·Anton PekcecHeidrun Potschka
Aug 3, 2006·Nature Reviews. Neuroscience·Carl P Wonders, Stewart A Anderson
Jan 25, 2007·The Journal of Comparative Neurology·Vladimir V Rymar, Abbas F Sadikot
May 22, 2007·Nature Reviews. Neuroscience·Bradley J MolyneauxJeffrey D Macklis
Sep 4, 2007·Brain Structure & Function·Lee A ShapiroCharles E Ribak
Sep 12, 2007·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Suzana Herculano-Houzel
Dec 3, 2008·The European Journal of Neuroscience·Y W J LiuR L M Faull
Dec 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Dragos IntaHannah Monyer
Jul 9, 2009·Epilepsia·Nisaharan SrikandarajahMaria Thom
Sep 19, 2009·Nature Reviews. Neuroscience·Pasko Rakic
Jul 6, 2010·Molecular and Cellular Neurosciences·Kun XiongXiao-Xin Yan
Sep 10, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fuzheng GuoDavid Pleasure
Nov 3, 2010·Cerebral Cortex·Amy A SarmaCharles A Greer
Jan 5, 2011·BMC Neuroscience·Jingzhong ZhangSebastien Couillard-Despres
Jan 20, 2011·The Journal of Comparative Neurology·Jocelyne BlochJean-François Brunet
Nov 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Diego GelmanOscar Marín
Mar 8, 2012·Current Pharmaceutical Design·Ilaria DecimoGuido Fumagalli
Oct 17, 2012·The European Journal of Neuroscience·Ulisses Martí-MengualJuan Nacher
Apr 4, 2013·European Journal of Histochemistry : EJH·E De NeviM Pumarola
Jul 16, 2014·Frontiers in Neuroanatomy·Ana HladnikZdravko Petanjek

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Citations

Nov 21, 2015·Developmental Neurobiology·Xue-Mei ZhangXiao-Xin Yan
Jun 7, 2017·Development, Growth & Differentiation·Jun HatakeyamaKenji Shimamura
May 18, 2019·Neural Plasticity·Lily WanXiao-Xin Yan
Nov 18, 2018·Frontiers in Veterinary Science·Chiara La Rosa, Luca Bonfanti
Jun 3, 2021·International Journal of Molecular Sciences·Jae-Yeon Kim, Mercedes F Paredes

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