Prenatal immune activation in mice blocks the effects of environmental enrichment on exploratory behavior and microglia density

Progress in Neuro-psychopharmacology & Biological Psychiatry
Jens BuschertOliver Ambrée

Abstract

Adverse environmental factors including prenatal maternal infection are capable of inducing long-lasting behavioral and neural alterations which can enhance the risk to develop schizophrenia. It is so far not clear whether supportive postnatal environments are able to modify such prenatally-induced alterations. In rodent models, environmental enrichment influences behavior and cognition, for instance by affecting endocrinologic, immunologic, and neuroplastic parameters. The current study was designed to elucidate the influence of postnatal environmental enrichment on schizophrenia-like behavioral alterations induced by prenatal polyI:C immune stimulation at gestational day 9 in mice. Adult offspring were tested for amphetamine-induced locomotion, social interaction, and problem-solving behavior as well as expression of dopamine D1 and D2 receptors and associated molecules, microglia density and adult neurogenesis. Prenatal polyI:C treatment resulted in increased dopamine sensitivity and dopamine D2 receptor expression in adult offspring which was not reversed by environmental enrichment. Prenatal immune activation prevented the effects of environmental enrichment which increased exploratory behavior and microglia density in NaC...Continue Reading

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Citations

Feb 24, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ashleigh L OsborneKatrina Weston-Green
Feb 13, 2020·Journal of Clinical Medicine·Clarissa CataleValeria Carola
Oct 13, 2018·Developmental Psychobiology·Amanda C KentnerSusanne Brummelte
Jul 20, 2019·International Journal of Molecular Sciences·Oliver AmbréeJudith Alferink
Sep 23, 2020·Developmental Neurobiology·Charlotte Isabelle Delage, Charlotte Anne Cornil
Oct 18, 2020·Molecular and Cellular Neurosciences·Jack Reddaway, Nichola M Brydges
Feb 2, 2021·The FEBS Journal·Praachi TiwariVidita A Vaidya
Oct 2, 2021·European Archives of Psychiatry and Clinical Neuroscience·Ralf BrischRainer Wolf

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