Prenatal immune challenge affects growth, behavior, and brain dopamine in offspring

Annals of the New York Academy of Sciences
Jan BakosD Jezova

Abstract

It is known that the development and plasticity of the neuroendocrine system can be affected by many factors, and that adverse events during the prenatal period can result in long-lasting changes in adulthood. This study was aimed at evaluating the possible consequences for offspring from chronic inflammation during pregnancy. Chronic inflammation was simulated by treatment with increasing doses of lipopolysaccharide (LPS) to dams on days 15 through 19 of pregnancy. Attempts were made to prevent possible negative alterations by keeping animals in an enriched environment (EE). Maternal exposure to LPS resulted in a significant reduction of body weight of male offspring during the weaning period. This difference remained until the age of 63 days in controls (C), but not in animals reared in EE. The content of dopamine in the nucleus accumbens was found to be lower in prenatally stressed (PS) adult males. Furthermore, prenatal exposure to maternal immune challenge was associated with lower locomotor activity in elevated plus maze and increased number of skips in the beam-walking test, as observed in female offspring. No differences in ACTH and corticosterone concentrations with regard to prenatal treatment were found; however, bot...Continue Reading

References

Oct 1, 1994·Pharmacology, Biochemistry, and Behavior·S J AlonsoM Rodriguez
Jun 1, 1994·The Journal of Clinical Investigation·J M ReulF Holsboer
Jan 8, 2000·Stroke; a Journal of Cerebral Circulation·B B Johansson
Apr 4, 2001·The European Journal of Neuroscience·E IsovichE Fuchs
Feb 9, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·ZaoDung LingPaul M Carvey

❮ Previous
Next ❯

Citations

Dec 8, 2011·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Hei Ming-YanJing-Jiang Wu
Dec 23, 2015·Neurotoxicology·A K AshleyM E Legare
Mar 29, 2011·Journal of Psychiatric Research·Neil M RichtandRobert K McNamara
Mar 9, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Michal A ElovitzIrina Burd
Jun 30, 2009·Neuroscience Letters·Heather KlintworthZhengui Xia
Jul 14, 2006·The European Journal of Neuroscience·Lir-Wan FanZhengwei Cai
Jan 24, 2009·Brain Research·Renata de Barros BrunoGlauce Socorro de Barros Viana
Jun 21, 2005·Neuroscience and Biobehavioral Reviews·Urs MeyerBenjamin K Yee
Sep 27, 2006·American Journal of Obstetrics and Gynecology·Robin RobersonCatherine Y Spong
Sep 15, 2005·American Journal of Obstetrics and Gynecology·Laura TosoCatherine Y Spong
Aug 21, 2013·Translational Neuroscience·Sarah E Canetta, Alan S Brown
Apr 29, 2014·Frontiers in Cellular Neuroscience·Gaurav SinghalBernhard T Baune
Jan 13, 2009·Behavioural Brain Research·Paul H Patterson
Aug 21, 2007·Journal of Neuroimmunology·Natalie Lasala, Heping Zhou
Aug 13, 2009·The Journal of Black Psychology·Serge MadhereCharmaine D M Royal
Aug 10, 2012·Journal of Leukocyte Biology·Wouter BeumerHemmo A Drexhage
Aug 1, 2015·Behavioural Pharmacology·Michela ServadioViviana Trezza
Dec 29, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kelly J BainesStephen J Renaud
Jan 22, 2020·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Jonghee Hong, Minji Bang
Mar 17, 2020·PloS One·Fritz TrillmichGábor Á Czirják
Aug 1, 2020·Frontiers in Immunology·Ricardo Wesley AlbercaMaria Notomi Sato
Apr 14, 2017·Physiological Research·R ZakariaB Al-Rahbi
Oct 5, 2018·Molecular Psychiatry·Kristi M SawyerCarmine M Pariante
Oct 14, 2017·International Journal of Bipolar Disorders·Dominik K E Beyer, Nadja Freund
Dec 10, 2020·Anais Da Academia Brasileira De Ciências·Marina G SilvaJucÉlia J Fortunato
Jan 1, 2021·Birth Defects Research·Christopher Harshaw, Anna G Warner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.