Prenatal intravenous cocaine and the heart rate-orienting response: a dose-response study

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Tara L FoltzCharles F Mactutus

Abstract

Attentional dysfunction is a persistent behavioral abnormality that is emerging as one of the cardinal features in the investigations of the teratogenic effects of cocaine in humans and rodents. The present study sought to extend this work by using a dose-response design with an alternate strain of rat. Virgin Long-Evans female rats, implanted with an IV access port prior to breeding were administered saline, 0.5, 1.0, or 3.0 mg/kg of cocaine HCl from gestational day (GD) GD8-21 (1x per day-GD8-14, 2x per day-GD15-21). Cocaine had no significant effect on maternal or litter parameters. At 14-15 days of age, 1 male and 1 female from each litter were tested to evaluate the heart rate orienting response (HR-OR). Following 20 min for acclimation, pups were presented an olfactory stimulus for 20s per trial, across four trials, and with an intertrial interval of 2 min. The initial baseline HR was not significantly different across the treatment groups, although cocaine did alter the stability of the QRS complex duration. The magnitude of the HR-OR averaged across trials increased as a linear function of dosage of cocaine. A more complex (quadratic) interaction between cocaine dose and sex of the offspring was also noted. When examine...Continue Reading

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Citations

Apr 20, 2006·BMC Neuroscience·Rosemarie M BoozeCharles F Mactutus
Dec 3, 2014·Neurotoxicology and Teratology·David S BennettMichael Lewis
Nov 29, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Dhyanesh Arvind PatelCharles F Mactutus
May 27, 2008·Biochemical and Biophysical Research Communications·Paola NavarroSergio Lavandero
Oct 16, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Mark J FerrisRosemarie M Booze
Aug 9, 2007·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Sandra J WeissCarolyn Harris-Muchell
Sep 24, 2004·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Diane M SnowCharles F Mactutus
Jul 4, 2006·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Daniel P BuxhoevedenCharles F Mactutus
Aug 22, 2015·BioMed Research International·Lucilia B LepschCritoforo Scavone
Nov 23, 2019·Journal of Neurochemistry·Hillary L CanslerDaniel W Wesson

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International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
D M SnowCharles F Mactutus
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