Prenatal ischemia reduces neuronal injury caused by neonatal hypoxia-ischemia in rats

Neuroreport
Zhengwei CaiPhilip G Rhodes

Abstract

To determine whether 'ischemic tolerance', first described in adult rodents, exists in fetal and neonatal rats, a comparison of brain injury was made between two groups of rat pups following neonatal hypoxia-ischemia (HI). One group of rat pups had previously been subjected to HI in utero (HI + HI); the other had been subjected to a sham operation (SH + HI). Brain infarct size and neuronal injury were measured 24 h after the neonatal HI insult. As indicated by 2,3,5-triphenyltetrazolium chloride staining and pathological examination, cerebral damage was significantly less in the HI+ HI group than in the SH + HI group. Induction of heat shock protein 70 (hsp70) was immunohistochemically detectable in both groups 24 h after the neonatal HI, and was proportional to the extent of tissue damage. The ischemic tolerance phenomenon observed in immature rats does not appear to be a result of induction of hsp70.

References

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Citations

Feb 11, 2000·Annals of the New York Academy of Sciences·S NishioK S Lee
Nov 20, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Takaaki Kirino
Mar 1, 2007·Seminars in Fetal & Neonatal Medicine·Carina Mallard, Henrik Hagberg
Feb 8, 2005·Seminars in Perinatology·Henrik HagbergAlan Leviton
Aug 18, 2001·Journal of Applied Physiology·G W Lu, H Y Liu

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