Prenatal lead exposure modifies the effect of shorter gestation on increased blood pressure in children.

Environment International
Alison P SandersMartha M Tellez-Rojo

Abstract

High blood pressure (BP) in childhood is frequently renal in origin and a risk factor for adult hypertension and cardiovascular disease. Shorter gestations are a known risk factor for increased BP in adults and children, due in part to a nephron deficit in children born preterm. As nephrogenesis is incomplete until 36 weeks gestation, prenatal lead exposure occurring during a susceptible period of renal development may contribute to programming for later life renal disease. The relationship between shorter gestation and children's BP has not yet been explored to identify i) critical windows using nonlinear piecewise models or ii) combined with other early life risk factors such as prenatal lead exposure. (1) To evaluate the nonlinear relationship between lower gestational age and childhood BP measured at 4-6 years of age, and (2) to investigate modification by prenatal lead exposure. In a prospective longitudinal birth cohort, we assessed 565 children between 4 and 6 years of age (mean: 4.8 years) in the PROGRESS cohort in Mexico City, Mexico. Gestational age at delivery was calculated using maternal report of last menstrual period (LMP) and confirmed with Capurro physical examination at birth. We measured pregnant women's bloo...Continue Reading

Citations

Oct 20, 2018·Current Environmental Health Reports·Emily C MoodyAlison P Sanders
Nov 2, 2019·Environmental Health : a Global Access Science Source·Yuri Levin-SchwartzRobert O Wright
Oct 2, 2020·Public Health Nutrition·Diana Cristina Soria-ContrerasRuy López-Ridaura
Feb 27, 2020·Current Developments in Nutrition·Rebecca K CampbellRobert O Wright
Nov 7, 2019·Clinical Obesity·Alejandra JáureguiAlejandra Cantoral
Aug 14, 2019·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Madiha Khalid, Mohammad Abdollahi
Nov 1, 2020·Environment International·Shohreh F FarzanMargaret R Karagas
Jul 30, 2019·Environmental Research·Anne M MullinHeather H Burris
Aug 28, 2021·Children·Yuri Levin-SchwartzAlison P Sanders

❮ Previous
Next ❯

Software Mentioned

Programming Research in Obesity , GRowth , Environment , and S...
Spacelabs
PROGRESS

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.