PMID: 9649610Jul 3, 1998Paper

Prenatal malnutrition-induced functional alterations in callosal connections and in interhemispheric asymmetry in rats are prevented by reduction of noradrenaline synthesis during gestation

The Journal of Nutrition
R Soto-MoyanoJ Belmar

Abstract

Prenatal malnutrition results in increased concentration and release of central noradrenaline, a neurotransmitter that is an important regulator of normal regressive events such as axonal pruning and synaptic elimination. This suggests that some of the functional disturbances in brain induced by prenatal malnutrition could be due at least in part to increased noradrenaline activity that may enhance regressive events during early stages of development. To test this hypothesis we studied whether chronic administration of alpha-methyl-p-tyrosine, an inhibitor of tyrosine hydroxylase, to rats during gestation might prevent long-term deleterious effects of prenatal malnutrition on functional properties of interhemispheric connections of the visual cortex, and on asymmetry of visual evoked responses. The experiments were conducted on normal and malnourished rats 45-50 d of age. Prenatal malnutrition was induced by restricting the food consumption of pregnant rats to 40%, from d 8 postconception to parturition. At birth, prenatally malnourished rats had significantly greater whole-brain noradrenaline concentration as well as significantly enhanced noradrenaline release in the visual cortex. At 45-50 d of age, the malnourished group ha...Continue Reading

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Citations

Nov 18, 2018·Nutrition Reviews·Rafael BarraAlejandro Hernández
Aug 26, 2006·The European Journal of Neuroscience·H PérezA Hernández
Apr 28, 2007·The International Journal of Neuroscience·Hernán PérezMartin Gotteland
May 30, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A R Del Angel-MezaI González-Burgos
Jan 28, 2014·The Journal of Endocrinology·F Aréchiga-CeballosP de Gortari
Feb 27, 2020·Trends in Neurosciences·Charles A Nelson, Laurel J Gabard-Durnam
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bernardita CayupeRafael Barra

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