Prenatal Mancozeb Exposure, Excess Manganese, and Neurodevelopment at 1 Year of Age in the Infants' Environmental Health (ISA) Study

Environmental Health Perspectives
Ana María MoraBerna van Wendel de Joode

Abstract

Although growing evidence suggests that early-life excess manganese (Mn) impairs neurodevelopment, data on the neurodevelopmental effects of mancozeb, a fungicide containing Mn, and its main metabolite ethylenethiourea (ETU) are limited. We examined whether prenatal mancozeb exposure and excess Mn were associated with neurodevelopment in 355 1-y-old infants living near banana plantations with frequent aerial mancozeb spraying in Costa Rica. We measured urinary ETU, hair Mn, and blood Mn concentrations in samples collected 1-3 times during pregnancy from mothers enrolled in the Infants' Environmental Health (ISA) study. We then assessed neurodevelopment in their 1-y-old infants using the Bayley Scales of Infant and Toddler Development, 3rd edition (BSID-III). We estimated exposure-outcome associations using linear regression models adjusted for maternal education, parity, gestational age at birth, child age, Home Observation for Measurement of the Environment score, and location of neurodevelopmental assessment. Median (P25-P75) urinary ETU, hair Mn, and blood Mn measured during pregnancy were 3.3 μg/L (2.4-4.9; specific gravity-corrected), 1.7 μg/g (0.9-4.1), and 24.0 μg/L (20.3-28.0), respectively. Among girls, higher ETU was ...Continue Reading

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Citations

Mar 8, 2020·International Journal of Environmental Research and Public Health·Ainara AndiarenaAitana Lertxundi
Apr 15, 2020·International Journal of Environmental Research and Public Health·Serena BianchiGuido Macchiarelli
Jun 15, 2019·Acta Neuropathologica·Jason R RichardsonAnumantha G Kanthasamy
Aug 8, 2020·Environmental Research·Douglas BarrazaBerna van Wendel de Joode
Mar 24, 2021·Environment International·Samuel FuhrimannAna M Mora
Mar 30, 2021·Current Epidemiology Reports·Julia A BauerBirgit Claus Henn
Apr 16, 2021·Environmental Research·Amaia IrizarAitana Lertxundi
Jun 3, 2021·International Journal of Environmental Research and Public Health·Judit Biosca-BrullMaria Teresa Colomina

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Methods Mentioned

BETA
urine sample collection
electrothermal atomic spectroscopy
ISA

Software Mentioned

Stata
R Development
R
StataCorp

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